疏肝法对情绪调节不良MCI患者工作记忆影响的机制研究

项目名称： 疏肝法对情绪调节不良MCI患者工作记忆影响的机制研究

项目编号： No.81473556

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 詹向红

作者单位： 河南中医药大学

项目金额： 75万元

中文摘要： 本课题在前期情志致衰研究基础上，围绕轻度认知功能障碍（MCI）的诊断、病因病机与治疗，针对MCI患者早期损伤最严重的认知成分- - 工作记忆，展开相关研究。通过问卷调查和神经心理评估进行病例对照研究，探索负性情绪积累与MCI发病的关系；借助ERPs和fMRI等神经影像学技术寻找MCI诊断的客观指标，并探讨从肝论治肝气郁结型MCI的疗效机制，以期把情志伤肝致衰置于更有说服力的科学水平之上，为MCI的诊断提供特异的客观依据，为中医药干预提供新视角，为肝主疏泄和七情内伤赋予新认识，为中医认知衰老理论增添新内涵。

中文关键词： 疏肝解郁；轻度认知功能障碍；工作记忆；事件相关电位；功能性磁共振成像

英文摘要： In this topic, based on the previous study of emotion causing aging, we focus on working memory, which is the most serious injury cognitive components in the early stage of the patients with mild cognitive impairment (MCI), and carry out the related researches from the diagnosis, etiology and pathogenesis, and treatment of MCI. The case-control study is carried out through questionnaire surveys and neuropsychological assessment, the relationships of negative emotions accumulation and onset of MCI are explored, objective indexes of MCI diagnosis are searched with the aid of neuroimaging techniques, such as event-related potentials (ERPs) and functional magnetic resonance imaging (fMRI), and the mechanisms of curative effects of the patients with MCI treated from the liver are explored, which belong to the syndrome of liver-qi stagnation. We hope to make the scientific theory of aging caused by emotion impairing liver more convincing, provide the specific and objective evidences for the diagnosis of MCI, and the new perspective for intervention of traditional Chinese medicine (TCM), give new understanding for the theory of liver controlling facilitating the cursing of qi, and increase the new connotation of the cognitive aging theory of TCM.

英文关键词： smoothing the liver therapy;mild cognitive impairment;working memory;event-related potentials;functional magnetic resonance imaging