精神分裂症患者感觉门控功能缺损机制的多模态神经影像研究

项目名称： 精神分裂症患者感觉门控功能缺损机制的多模态神经影像研究

项目编号： No.81471650

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 黄力

作者单位： 暨南大学

项目金额： 73万元

中文摘要： 精神分裂症是一种病因不明的重度精神疾病，具有很大的致残性。感觉门控功能缺损被认为是该病的重要发病机制理论，但发生机制至今未明。本课题组前期研究发现精神分裂症感觉门控缺损可影响后期注意参与的认知过程；且门控缺损与听皮层异常有关。同时，还发现患者前额叶和海马代谢异常。结合文献，我们提出精神分裂症感觉门控缺损是由听皮层、前额叶、海马、丘脑等改变而导致的神经环路异常，且与alpha-7尼古丁乙酰胆碱受体系统缺陷相关。本项目拟应用认知心理测试工具、脑磁图及多模态磁共振成像、和外周血alpha-7受体 mRNA及蛋白检测，分析患者感觉门控相关的认知功能、脑电磁反应及脑结构/功能状态、和外周生物指标之间的关系；同时，结合精神分裂症动物模型探讨脑内alpha-7受体对感觉门控功能的调节机制。本项目预期将揭示精神分裂症感觉门控功能缺损的神经生物学机制。为精神分裂症病因学提供实证依据，并为其治疗提供新的思路。

中文关键词： 功能磁共振成像；脑磁图；精神分裂症；多模态；感觉门控

英文摘要： Schizophrenia is a chronic, severe, and disabling mental disorder, but the etiology have not been fully elucidated. Sensory gating deficitis is considered to be characteristic of schizophrenia biological markers, but the mechanism is still not clear. Our group found that schizophrenia patients have auditory gating deficits at both pre-attentive and early attentive levels, which might be related to superior temporal gyrus structural abnormality. We also found metabolite abnormalities in prefrontal and hippocampus in schizophrenia patients. Therefore, we propose sensory gating deficitis is caused by abnormal neural circuits including the auditory cortex, prefrontal cortex, hippocampus, and hypothalamus , and which would be linked to α7nAChRs (alpha 7 nicotinic acetylcholine receptors) system defects. In this study, this project uses the cognitive psychological evaluation, magnetoencephalography and the multimodal magnetic resonance imaging technologies, and blood α7nAChRs level detection method study of schizophrenia patients and healthy controls, in order to observe the sensory gating abnormal neural circuits by brain magnetic fields, function, structure and peripheral biological markers. In additional, the animal models be used, to verify the brain α7nAChRs and sensory gating neural circuits relationship.The project is expected to provide a reference to etiology in schizophrenia, and to provide a new direction for treatment.

英文关键词： functional magnetic resonance imaging;magnetoencephalography;schizophrenia;multimodal;sensory gating