卟啉酞菁功能配合物-无机纳米复合体的组装及在比色生物传感中的应用

项目名称： 卟啉酞菁功能配合物-无机纳米复合体的组装及在比色生物传感中的应用

项目编号： No.21271119

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 数理科学和化学

项目作者： 刘青云

作者单位： 山东科技大学

项目金额： 75万元

中文摘要： 由于卟啉、酞菁化合物具有特殊的大环结构，使其在光、电、磁、催化等领域展现出巨大的应用前景。卟啉、酞菁化合物与功能性无机纳米材料构筑的复合材料能够克服单一材料的缺点，已经引起不同领域科学家的广泛兴趣。本课题拟以设计合成的卟啉、酞菁化合物组装成纳米聚集体，进一步将其与无机纳米材料(贵金属、氧化物等)组装成纳米复合结构，并构建比色生物传感应用于催化检测过氧化氢。我们将从以下方面研究结构、形貌与性能之间的关系：(1)大环化合物的取代基长度、种类和推、拉电子效应对组装的纳米聚集体形貌的影响；(2)纳米复合体的组成、结构与大环分子排列有序性长短之间的关系；(3)用于构筑比色生物传感器的纳米复合体，其结构和组成在催化检测过氧化氢过程中对电子转移的影响。基于这些研究，优化大环化合物的分子结构、纳米聚集体的形貌和复合材料的组成，为构筑更高效的比色生物传感器提供新的思路和方法。

中文关键词： 卟啉；纳米复合材料；比色；过氧化物酶；过氧化氢

英文摘要： Porphyrin and phthalocyanie complexes have shown great perspective of application in optical, electronic, magnetic and catalytic fields, as they bear special macrocyclic structures. Nanocomposites, which are composed of functional inorganic nanomaterials and porphyrin/phthalocyanie complexes, have caused wide interests of scientists in different fields because they can overcome the defects of single materials. In this project, we will assemble nanoaggregates by designing porphyrin and phthalocyanie complexes, further assemble them into nanocomposite structures with inorganic nanomaterials such as precious metals and oxides, and construct colorimetric biosensors to be used in catalytic detection of hydrogen peroxide. We will investigate the relations of structures, morphologies and properties in the following aspects: (1) the influences of length, type and electronic effect of substituents of macrocyclic compounds on morphologies of assembled nanoaggregates; (2) the relations between composition, structure of nanocomposites and length of ordered arrangement of macrocyclic molecules; and (3) the influences of the structures and compositions of nanocomposites constructed to the colorimetric biosensors on electron transfer during catalytic detection of hydrogen peroxide. Based on these investigations, we will optim

英文关键词： porphyrin；nanocomposite；colorimetric；peroxdiase；H2O2