针刺、语言任务干预卒中后运动性失语的fMRI/ERP双模态脑网络效应机制研究

项目名称： 针刺、语言任务干预卒中后运动性失语的fMRI/ERP双模态脑网络效应机制研究

项目编号： No.81473654

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 常静玲

作者单位： 北京中医药大学

项目金额： 74万元

中文摘要： 以额叶损伤为主的脑卒中后运动性失语患者为研究对象，将病例随机纳入针刺组、语言任务组、针刺+语言任务组及空白组，以前期临床有效的针刺加语言康复综合治疗方案为干预手段，在肾-脑相关、形神合一的中医理论指导下，对入组患者给予针刺+语言康复训练+内科基础综合治疗方案干预60天，并在入组当天、干预后60天进行语言学量表测评、fMRI /ERP测评及实验，发挥神经语言学、神经影像学、神经电生理学的多学科交叉，以语言学量表、fMRI、ERP为评价手段，借鉴功能磁共振影像、神经电生理的脑结构与功能网络分析技术、事件相关电位(ERP)与功能磁共振影像（fMRI）融合技术，横向观察针刺、语言任务、针刺+语言任务分别激活的脑结构与功能网络；纵向观察针刺加语言康复训练综合治疗前后的语言功能和脑网络动态变化，探索额叶损伤后运动性失语患者语言功能恢复的脑网络变化规律与模式，为针刺加语言康复训练综合治疗提供疗效证据。

中文关键词： 卒中后运动性失语；针刺；语言任务；fMRI/ERP；脑网络

英文摘要： The patients of motor aphasia after stroke with the injury of frontal lobe involved were taken as the subjects. They were randomized into an acupuncture group, a language task group, an acupuncture + language task group and a blank group. The effective comprehensive therapeutic program of acupuncture and language rehabilitation at the early stage was applied clinically as the intervention approach. Under the guide of kidney-brain coordination and the body-mind unity in the theory of traditional Chinese medicine, the intervention was given for 60 days with the basic comprhensive therapeutic program of acupuncture + comprehensive languages training + basic medical treatment. On the date of group enrolment and in 60 days of intervention, linguistic scale assessment, fMRI/ERP assessment and experiment were adopted separately. Bringing the roles of multi-interdisciplinary into play, such as traditional Chinese medicine, linguistics and neuroelectrophysiology, using linguistic scale, fMRI and ERP as the approach to assessment and in reference to fMRI, brain structure and function network analystic technology of neuroelectrophysiology and the fusion technology of event related potential (ERP) and fMRI, the brain structure and function network were observed transversely after the treatment with acupuncture, language task and acupuncture + langugage task separately. The dynamic changes in language function and brain network were observed longitudinally before and after the comprehensive treatment with acupuncture and language training. Finally, the law and pattern of brain network changes in the language function recovery was explored for the patients of motor aphasia after stroke with the injury of frontal lobe involved so as to provide the evidence on the efficacy of the comprehensive therapy of acupuncture and language training.

英文关键词： Motor aphasia after stroke;Acupuncture;Language tasks;fMRI/ERP;Brain network