基于多模态信息的针刺治疗中风后抑郁效应评价

项目名称： 基于多模态信息的针刺治疗中风后抑郁效应评价

项目编号： No.81460273

项目类型： 地区科学基金项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 陈洪波

作者单位： 桂林电子科技大学

项目金额： 47万元

中文摘要： 针刺是治疗中风后抑郁(PSD )患者的重要手段之一，但针对针刺治疗PSD疗效的系统性评价、作用机制方面的研究还相对较少，缺少安慰针刺治疗的对照实验，无法准确判断针刺在治疗过程中起到的是治疗作用还是安慰剂的作用。本项目拟分别采取独立分量分析(ICA)方法和局域一致性(ReHo)算法对静息态fMRI数据进行处理，检测脑功能网络中各个脑区的ROI，并计算其连接强度，研究ICA和ReHo方法在脑功能图像数据处理中的性能差异；研究静息态fMRI数据中的独立成分构成；研究PSD独立分量的特性及提取方法；研究ReHo方法中的种子点选取策略。同时，采集PSD患者诱发电位，并评估PSD患者的脑功能连接, 研究少次提取PSD患者视/听觉诱发电位的方法。采取基于安慰针刺的治疗PSD的对照实验方案，综合多模态信息，力求揭示针刺治疗PSD的效应和作用机制，为验证针刺治疗神经性疾病疗效提供客观性的评估方法。

中文关键词： 静息态功能磁共振；多模态信息；针刺治疗；中风后抑郁

英文摘要： Post-stroke depression (PSD) is one of the familiar complications of the stroke. Its long-term existence influences the recovery of the nerve function for stoke patients obviously. And it cause that the mortality rate of stoke patients is increased. Acupuncture therapy is one of the popular therapeutic tools for PSD, because it is convenient, low price and has no adverse reaction. However, the research of the systemic evaluation and functional mechanisms for PSD patients treated by acupuncturing is still relatively scarce. In the existing experimental scheme of curative effect for acupuncture treatment, it is lack of the control experiment of sham acupuncture. So, it is unable to accurately estimate that the acupuncture plays the therapeutic effect or the placebo effect in the treatment process. In this project, we will select the control experiment scheme for acupuncture curative effect evaluation in which the sham acupuncture is used. In the earlier research experience, we have get the independent component analysis method, and applied it into image denoising and evoked potential extraction. The aim of this project is to reveal the curative effect and functional mechanisms of the acupuncture in PSD treatment.

英文关键词： resting-state fMRI;multimodal information;Acupuncture therapy;post-stroke depression