多模态MRI技术指导非小细胞肺癌个体化放疗生物靶区研究

项目名称： 多模态MRI技术指导非小细胞肺癌个体化放疗生物靶区研究

项目编号： No.81472814

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 于会明

作者单位： 北京大学

项目金额： 75万元

中文摘要： 基于群体化证据的放疗技术不适合存在巨大差异的非小细胞肺癌（NSCLC）患者，肿瘤异质性是决定NSCLC放疗个体差异的主要因素之一，根据肿瘤异质性勾画个体化生物靶区是目前研究热点之一。多模态磁共振（MRI）技术(包括常规MRI、波谱成像、扩散加权成像等)可以立体显示肿瘤异质性特征，克服CT影像局限性，使NSCLC个体化放疗成为可能。为克服基于群体化证据设计放疗方案的不足，本项目在前期研究基础上，拟以肺癌细胞、肺癌动物模型和临床患者为对象，通过影像-病理标本-分子指标精确匹配对照、图像融合等手段，充分挖掘多模态MRI显像信息，研究影像特征和成像参数与肺癌放疗敏感性指标、侵袭性和危及器官的关系，探索基于多模态MRI技术精确预测肿瘤内亚区域放疗敏感性、侵袭范围和危及器官的方法及技术标准，并据此勾画生物靶区进行个体化生物调强放疗。本研究将建立NSCLC生物放疗新模式，为个体化放疗提供理论和实践依据。

中文关键词： C05_气管；支气管；肺肿瘤；核磁共振；生物靶区；图像融合；放射治疗

英文摘要： The standard radiotherapy based on population evidence is unfit for non-small cell lung caner(NSCLC) with heterogeneity. Tumor heterogeneity is associated with disease progression and malignancy, and may have important effects on the results of treatment. Therefore, the discovery of novel radiotherapy strategies based on personal tumor heterogeneity is one of the hotspots in radiotherapy study. Multimodal magnetic resonance imaging (MRI) technology may be an emerging powerful tool for evaluation of tumor heterogeneity because of its unrivaled advantages of non invasiveness, three-dimensional, and dynamic display, which turns the personal radiotherapy into reality. MRI plays a pivotal role in the management of patients with cancer. This technique including proton MR spectroscopy (MRS), diffusion weighted imaging (DWI),pulmonary perfusion imaging using MRI (pMRI), dynamic contrast-enhanced MR(DCE-MR) and functional MRI (fMRI) may be an emerging powerful tool for evaluation of invasiveness and radiosensitivity of NSCLC. In order to overcome the disadvantages of the design of radiotherapy scheme based on population evidence,based on our previous study, we will use lung cancer cells, lung cancer animal models and clinical patients as the research objects in this study to make full use of the multimodal MRI functional imaging information by imaging - pathological specimens - molecular markers precise control study. We will also study the relationship between the imaging features, parameters or the biological index and tumor invasiveness, radiotherapy sensitivity and organs at risk by image fusion, pathological precise matching technology. Third, we will explore the method and relevant technical standards of multimodality MRI delineation of individual biological target,accurate prediction of tumor subregional radiotherapy sensitivity, invasion, and organs at risk based on multimodal MRI technology with accurate radiotherapy technology integration,and then draw the outline of biological target for individual biological intensity-modulated radiotherapy. This study will establish a new model of NSCLC biological radiotherapy to provide theoretical and practical basis for individualized radiotherapy.

英文关键词： Lung cancer;Magnetic resonance imaging;Biological target volume;Image fusion;Radiotherapy