基于多模态MRI技术的糖尿病中枢神经系统早期微血管病变预警体系的建立

项目名称： 基于多模态MRI技术的糖尿病中枢神经系统早期微血管病变预警体系的建立

项目编号： No.81471636

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 崔光彬

作者单位： 中国人民解放军第四军医大学

项目金额： 70万元

中文摘要： 糖尿病（主要是II型糖尿病）损害中枢神经系统（CNS）功能，尤其是导致轻度认知损害（MCI），增加进展为痴呆的风险。以往认为神经变性导致糖尿病MCI，近年发现微血管病变可能是其早期机制，但目前尚缺乏糖尿病患者早期微血管病变的预警体系。最新神经影像学技术可以测量大脑微血流、血脑屏障（BBB）和核团铁沉积，反映CNS的微血管病变，但操作复杂，不能全面反映微血管病变。本课题组前期观察到44.4%的糖尿病患者出现MCI，采用多模态MRI技术可以同时测量大脑微血流、BBB和核团铁沉积，提高了监测微血管病变的信度和效度。因此，我们拟综合心理行为学和临床生化等指标,利用多模态MRI技术建立糖尿病早期微血管病变的预警体系。并在糖尿病大鼠模型上通过干预血糖水平，测试该预警体系的灵敏度和特异度。该预警体系将有可能协助筛选糖尿病微血管病变患者，进行早期干预，对预防和延缓其向痴呆发展具有重要的理论和临床实践意义。

中文关键词： 磁共振成像；神经影像；多模态；中枢神经系统

英文摘要： Diabetes ( mainly type II diabetes ) lead to the central nervous system (CNS) function impairment, especially the mild cognitive impairment (MCI) that increased the risk of progression to dementia. It was regarded that neurodegeneration contributes to the diabetic MCI, however, recent research suggested that CNS microvascular alterations are the mechanism for early diabetic MCI. But there still lacks an early warning system for the CNS micro-vascular alterations during early diabetes. Latest neuroimaging techniques enable the measurement of brain blood flow, blood-brain barrier (BBB) and the nuclei deposition of iron to reflect CNS microvascular alterations. But these techniques are complicated and can not fully reflect the microangiopathy with one single technique. We previous observed that 44.4% of diabetic patients demonstrate MCI and established the coprehenive protocols of measuring brain blood flow, BBB and the nuclei deposition of iron simultanosly based on the multimodal MRI technique so as to relect the microvascular alterations reliablly and validibly. Therefore, we intend to integrate psychological mesurement and clinical biochemical examination, and to establish the early warning system for the central nervous system micro-vascular alterations during early diabetes based on the multi-modal MRI technique. The reliability and validity of this sysem will be testd in the diabetic rat model. The early warning system will likely assist in screening patients with diabetic microvascular alterations, to perform early intervention so as to prevent or delay the progression from diabetic MCI to dementia.

英文关键词： MRI;Neuroimage;Multimodal;Central nervous system