医用镁合金表面载银抗菌Ca-P-Si涂层的制备与生物相容性研究

项目名称： 医用镁合金表面载银抗菌Ca-P-Si涂层的制备与生物相容性研究

项目编号： No.51301123

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 一般工业技术

项目作者： 杜辉

作者单位： 武汉科技大学

项目金额： 25万元

中文摘要： 镁合金具有良好的生物相容性和与自然骨相匹配的力学性能，且能生物降解，因此镁合金作为骨植入材料具有独特的优越性。但镁合金在人体环境中降解速率过快，使合金在骨组织愈合之前过早地丧失了力学性能，限制了其应用。在镁合金表面制备涂层是解决该问题最有效的方法之一。本项目以申请人前期研究的Mg-Zn-Mn-Ca合金为研究对象，采用化学转化法对其进行表面生物改性处理，在镁合金表面制备载银抗菌Ca-P-Si复合涂层。在深刻揭示生物转化膜成膜机理的基础上，进一步采用电化学和浸泡实验探索涂层特征对镁合金降解速率和腐蚀进程的影响机制。最后，对表面改性后的镁合金进行体外和体内的生物相容性评价，揭示涂层中银离子和硅离子对生物相容性的耦合作用机制。本项目所研究的活性涂层有望显著降低镁合金的降解速率，促进骨组织的形成和愈合，并抑制植入初期炎症的发生。因此，本项目将为医用镁合金的开发和应用提供重要的理论和实验依据。

中文关键词： 镁合金；腐蚀；抗菌；涂层；电化学测试

英文摘要： Magnesium alloys have shown special applications as bone implant materials due to their good biocompatibility, biodegradability and close mechanical property to nature bones. However, the main limitation in the implementation of magnesium alloys as an orthopedic biomaterial is that the rapid degradation leads to the losing of the mechanical property before the formation of stable tissue around the implant. Preparation of coating on magnesium alloys is one of the most effective methods to solve the problem. In this subject, Mg-Zn-Mn-Ca alloys were chosen as the research subject. Chemical reaction method was used to prepare the silver ions-substituted Ca-P-Si anti-bacterial coating on the surface of Mg-Zn-Mn-Ca alloys. Based on revealing the formation mechanism of the coversion coating, the effect mechanisms of coating characteristic are explored by the electrochamical and immersion measurments. The conversion coating could improve the corrosion resistance of magnesium alloys, promote bioactivity of bone cell and accelerate bone healing. Finally, the biocompatibilities of the conversion treated Mg-Zn-Mn-Ca alloys are evaluated both in-vitro and in-vivo, and reveal the influnce mechanism of Ag iron on the biocompatibilities. This subject hopes to improve the degration rate of magnesium alloys, promote bone healing

英文关键词： Magnesium alloy；corrosion；anti-bacterial；coating；electrochemical tests