雷公藤甲素诱导急性早幼粒白血病细胞凋亡及自噬的机制研究

项目名称： 雷公藤甲素诱导急性早幼粒白血病细胞凋亡及自噬的机制研究

项目编号： No.31470074

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 生物科学

项目作者： 赵万红

作者单位： 西安交通大学

项目金额： 30万元

中文摘要： 本项目以急性早幼粒细胞白血病（Acute promyelocyte leukemia，APL）为研究对象，从小分子药物诱导细胞凋亡及自噬的角度入手，以雷公藤甲素衍生物作为小分子干预手段，结合APL发病及耐药的生理病理微环境理论，拟证实雷公藤甲素可有效诱导AML细胞发生凋亡及自噬，评估雷公藤甲素作为APL治疗药物的可能性，为新型抗AML药物的研发奠定基础。

中文关键词： 急性早幼粒细胞白血病；雷公藤甲素；凋亡；自噬；

英文摘要： Acute promyelocyte leukemia (APL) is a kind of malignant clone disease in haemopoetic stem cells．Plenty of abnormal archaeoeytes and juvenile cells proliferate in marrow, and infiltrate generally in all kinds of organs and suppress the haematopoiesis．Triptolide, isolated from the herb Tripterygium wilfordii, as well as some of its derivants has been shown to potently induce apoptosis and autophagy in various malignant cells by inhibiting RNA synthesis and nuclear factor-κB activity. In this project, we aim to confirm whether APL cells can be induced to apoptosis and autophagy by triptolide effectively. Furthermore, we also focus on exploring the molecular mechanism of triptolide induced apoptosis and autophagy. The answers to these questions will lay a foundation for the development of new anti-APL drugs.

英文关键词： APL；triptolide；apoptosis；autophagy；