Accurate and explainable health event predictions are becoming crucial for healthcare providers to develop care plans for patients. The availability of electronic health records (EHR) has enabled machine learning advances in providing these predictions. However, many deep learning based methods are not satisfactory in solving several key challenges: 1) effectively utilizing disease domain knowledge; 2) collaboratively learning representations of patients and diseases; and 3) incorporating unstructured text. To address these issues, we propose a collaborative graph learning model to explore patient-disease interactions and medical domain knowledge. Our solution is able to capture structural features of both patients and diseases. The proposed model also utilizes unstructured text data by employing an attention regulation strategy and then integrates attentive text features into a sequential learning process. We conduct extensive experiments on two important healthcare problems to show the competitive prediction performance of the proposed method compared with various state-of-the-art models. We also confirm the effectiveness of learned representations and model interpretability by a set of ablation and case studies.
翻译:准确和可解释的保健事件预测对于保健提供者制定病人护理计划至关重要。电子保健记录(EHR)的提供使提供这些预测的机械学习进步成为了机器学习的进展。然而,许多深层次的学习方法在解决几个重大挑战方面不能令人满意:(1) 有效利用疾病领域知识;(2) 合作学习病人和疾病;(3) 纳入未经结构化的文本。为了解决这些问题,我们提议了一个合作图表学习模型,以探讨病人-疾病相互作用和医疗领域知识。我们的解决方案能够捕捉病人和疾病的结构特征。拟议的模型还利用非结构化文本数据,采用关注调控战略,然后将关注的文字特征纳入连续学习过程。我们对两个重要的保健问题进行了广泛的实验,以显示拟议方法与各种最新模式相比的竞争性预测性表现。我们还确认通过一系列的通缩和案例研究,学习的表述和模型解释的有效性。