Adversarial attacks pose a challenge to the deployment of deep neural networks (DNNs), while previous defense models overlook the generalization to various attacks. Inspired by targeted therapies for cancer, we view adversarial samples as local lesions of natural benign samples, because a key finding is that salient attack in an adversarial sample dominates the attacking process, while trivial attack unexpectedly provides trustworthy evidence for obtaining generalizable robustness. Based on this finding, a Pixel Surgery and Semantic Regeneration (PSSR) model following the targeted therapy mechanism is developed, which has three merits: 1) To remove the salient attack, a score-based Pixel Surgery module is proposed, which retains the trivial attack as a kind of invariance information. 2) To restore the discriminative content, a Semantic Regeneration module based on a conditional alignment extrapolator is proposed, which achieves pixel and semantic consistency. 3) To further harmonize robustness and accuracy, an intractable problem, a self-augmentation regularizer with adversarial R-drop is designed. Experiments on numerous benchmarks show the superiority of PSSR.
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