While scientists increasingly recognize the importance of metadata in describing their data, spreadsheets remain the preferred tool for supplying this information despite their limitations in ensuring compliance and quality. Various tools have been developed to address these limitations, but they suffer from their own shortcomings, such as steep learning curves and limited customization. In this paper, we describe an end-to-end approach that supports spreadsheet-based entry of metadata while providing rigorous compliance and quality control. Our approach employs several key strategies, including customizable templates for defining metadata, integral support for the use of controlled terminologies when defining these templates, and an interactive Web-based tool that allows users to rapidly identify and fix errors in the spreadsheet-based metadata they supply. We demonstrate how this approach is being deployed in a biomedical consortium to define and collect metadata about scientific experiments.
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