False discovery rate (FDR) is a common way to control the number of false discoveries in multiple testing. There are a number of approaches available for controlling FDR. However, for functional test statistics, which are discretized into $m$ highly correlated hypotheses, the methods must account for changes in distribution across the functional domain and correlation structure. Further, it is of great practical importance to visualize the test statistic together with its rejection or acceptance region. Therefore, the aim of this paper is to find, based on resampling principles, a graphical envelope that controls FDR and detects the outcomes of all individual hypotheses by a simple rule: the hypothesis is rejected if and only if the empirical test statistic is outside of the envelope. Such an envelope offers a straightforward interpretation of the test results, similarly as the recently developed global envelope testing which controls the family-wise error rate. Two different adaptive single threshold procedures are developed to fulfill this aim. Their performance is studied in an extensive simulation study. The new methods are illustrated by three real data examples.
翻译:假发现率(FDR)是控制多次测试中虚假发现次数的常见方法。有一些方法可用于控制FDR。但是,对于功能性测试统计,这些测试统计被分解为百万美元高度关联的假设,这些方法必须说明整个功能领域和关联结构分布的变化。此外,将测试统计及其拒绝或接受区域进行视觉化,具有极大的实际意义。因此,本文件的目的是根据重试原则,找到一个图形信封,控制FDR,通过简单规则检测所有个人假设的结果:假设只有在经验性测试统计不在信封内时才会被拒绝。这样的信封可以直接解释测试结果,类似于最近开发的用于控制家庭误差率的全球信封测试。为了达到这个目的,制定了两种不同的适应性单一门槛程序。在一次广泛的模拟研究中研究了它们的性能。三个真实数据示例说明了新的方法。