Blood oxygen saturation (SpO2) is a crucial vital sign routinely monitored in medical settings. Traditional methods require dedicated contact sensors, limiting accessibility and comfort. This study presents a deep learning framework for contactless SpO2 measurement using an off-the-shelf camera, addressing challenges related to lighting variations and skin tone diversity. We conducted two large-scale studies with diverse participants and evaluated our method against traditional signal processing approaches in intra- and inter-dataset scenarios. Our approach demonstrated consistent accuracy across demographic groups, highlighting the feasibility of camera-based SpO2 monitoring as a scalable and non-invasive tool for remote health assessment.
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