Biological processes underlying the basic functions of a cell involve complex interactions between genes. From a technical point of view, these interactions can be represented through a graph where genes and their connections are, respectively, nodes and edges. The main objective of this paper is to develop a statistical framework for modelling the interactions between genes when the activity of genes is measured on a discrete scale. In detail, we define a new algorithm for learning the structure of undirected graphs, PC-LPGM, proving its theoretical consistence in the limit of infinite observations. The proposed algorithm shows promising results when applied to simulated data as well as to real data.
翻译:细胞基本功能所依据的生物过程涉及基因之间的复杂相互作用。从技术角度来看,这些相互作用可以通过一个图来表示,其中基因及其连接分别是节点和边缘。本文件的主要目的是建立一个统计框架,用于模拟基因活动以离散尺度测量基因活动时基因之间的相互作用。详细来说,我们为学习非定向图的结构确定了一种新的算法PC-LPGM, 证明它在无限观测范围内的理论一致性。提议的算法在应用到模拟数据和真实数据时显示了有希望的结果。