In the 1958 paper "Shall we count the living or the dead?", Mindel C. Sheps proposed a principled solution to the familiar problem of asymmetry of the relative risk. We provide causal models to clarify the scope and limitations of Sheps' line of reasoning, and show that her preferred variant of the relative risk will be stable between patient groups under certain biologically interpretable conditions. Such stability is useful when findings from an intervention study must be generalized to support clinical decisions in patients whose risk profile differs from the participants in the study. We show that Sheps' approach is consistent with a substantial body of psychological and philosophical research on how human reasoners carry causal information from one context to another, and that it can be implemented in practice using van der Laan et al's Switch Relative Risk, or equivalently, using Baker and Jackson's Generalized Relative Risk Reduction (GRRR).
翻译:Mindel C. Sheps在1958年的论文“我们算算活人还是死人?” 中,Mindel C. Sheps提出了解决已知的相对风险不对称问题的原则性解决办法。我们提供了因果模型,以澄清Sheps推理路线的范围和局限性,并表明她所偏爱的相对风险变量在某些可生物解释的条件下在病人群体之间是稳定的。当干预研究的结果必须普遍化,以支持风险状况与研究参与者不同的病人的临床决定时,这种稳定性是有用的。我们表明,Sheps的方法与大量关于人类理性者如何从一个环境向另一个环境传播因果信息的心理和哲学研究是一致的,并且可以在实践中使用van der Laan et al的切换相对风险,或者同等地使用贝克和杰克逊的普遍相对风险减少(GRRR ) 。