Efficient Covariate Adjustment in Stratified Experiments

This paper studies covariate adjusted estimation of the average treatment effect (ATE) in stratified experiments. We work in the stratified randomization framework of Cytrynbaum (2021), which includes matched tuples designs (e.g. matched pairs), coarse stratification, and complete randomization as special cases. Interestingly, we show that the Lin (2013) interacted regression is generically asymptotically inefficient, with efficiency only in the edge case of complete randomization. Motivated by this finding, we derive the optimal linear covariate adjustment for a given stratified design, constructing several new estimators that achieve the minimal variance. Conceptually, we show that optimal linear adjustment of a stratified design is equivalent in large samples to doubly-robust semiparametric adjustment of an independent design. We also develop novel asymptotically exact inference for the ATE over a general family of adjusted estimators, showing in simulations that the usual Eicker-Huber-White confidence intervals can significantly overcover. Our inference methods produce shorter confidence intervals by fully accounting for the precision gains from both covariate adjustment and stratified randomization. Simulation experiments and an empirical application to the Oregon Health Insurance Experiment data (Finkelstein et al. (2012)) demonstrate the value of our proposed methods.