基于压平和3-D DIC的角膜生物力学性能活体检测方法及技术研究

项目名称： 基于压平和3-D DIC的角膜生物力学性能活体检测方法及技术研究

项目编号： No.61471003

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 无线电电子学、电信技术

项目作者： 张学勇

作者单位： 安徽建筑大学

项目金额： 83万元

中文摘要： 精确测量角膜生物力学性能对近视眼准分子激光角膜屈光手术指导评估和青光眼诊治具有重要作用。现有的检测方法如角膜拉伸法、膨胀法和光学干涉法等，由于采用的技术大多是对角膜进行离体测量，因而不能真实反映活体角膜的生物力学性能。为此，本项目拟开展角膜生物力学性能活体检测方法和技术研究。首先从眼科临床采用的压平式眼压检测方法出发，研究一种能实时同步检测角膜变形压平力、压平面积和压平位移的角膜变形压平式眼压测量新方法；然后发展研究角膜弹性模量、眼壁硬度、蠕变与滞后等力学性能压平式活体检测方法；最后开展三维数字图像相关（3-D DIC）在角膜生物力学性能活体非接触全场光学检测方面的应用技术研究，完成对角膜变形、应变及蠕变、滞后和松弛性能的系统研究，丰富角膜生物力学性能活体检测内容与检测手段。项目研究工作对活体眼角膜变形机制理解、近视眼屈光手术计划和Goldmann眼压测量值误差修正具有重要理论和实际意义。

中文关键词： 医学生理信息检测；眼压压平测量法；角膜生物力学性能活体测量；实时监测；三维数字图像相关

英文摘要： A precise measurement of the biomechanical properties of the ocular cornea, such as the stress, strain, stress relaxation, elasticity modulus, hysteresis and ocular rigidity , is very important not only in the guiding and evaluation of the laser corneal refractive surgery for myopia but also in the diagnosis and treatment about the glaucoma and corneal diseases.These inspection technologies of the biomechanical properties measurement in vitro,such as the corneal extension testing, the corneal inflation testing , the optical interferometry , and the whole ocular eyeball perfusion testing, cannot effectively achieve the biomechanical parameter measurement in vivo ,because they destroyed the physiological environment and the intrinsic structure of the cornea .Therefore, it is necessary to develop a non-invasive inspection technology for the measurement of the corneal biomechanical properties in vivo.In this application,several inspection techniques, aimed to achieve the in vivo measurement of the biomechanical parameters of the ocular cornea,are investigated in detailed.For the purpose of real-time detecting the applanation area, displacement and the force exerted to the cornea during applanation tonometry,a new method has been investigated.Based on the method,a new applanation technique for measuring the elasticity modulus,creep and hysteresis behavior of the ocular cornea in vivo is proposed and further a new inspection technology of the ocular rigidity measurement in vivo is investigated.Applications of the three-dimensional digital image correlation (3-D DIC) method for the determination of the biomechanical behavior of the ocular cornea under the inflation conditions are investigated. Using 3D-DIC the full-field displacements on the surface of the corneal sample are calculated and the biomechanical behavior of the ocular cornea,such as creep, hysteresis and stress relaxation, is also tested.Based on these results, the mechanism of ocular cornea deformation under the physiological environment is fully understood ,the laser corneal refractive surgery can be best planned,and intraocular pressure measurement errors with Goldmann applanation tonometer may be corrected. In conclusion,the research results on this project are exceedingly valuable for the clinical practice.

英文关键词： medical physiology information detection;applanation tonometry;measurement of biomechanical properties of ocular cornea in vivo;real-time detection;three-dimensional digital image correlation(3-D DIC)