聚合物可降解血管支架服役过程力学性能演化机理及其结构优化设计

项目名称： 聚合物可降解血管支架服役过程力学性能演化机理及其结构优化设计

项目编号： No.11502044

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 数理科学和化学

项目作者： 李红霞

作者单位： 大连理工大学

项目金额： 22万元

中文摘要： 研究聚合物血管支架服役过程材料降解和力学性能演化机理，是解决其结构设计问题的基础。本项目针对现有支架在治疗过程中对人体带来的严重医源性损伤问题，提出聚合物可降解支架力学性能及其演化规律与各阶段医学要求相匹配的支架结构优化设计方案。从细观力学角度研究聚合物血管支架在材料降解和结构耦合作用下的力学性能及其演化规律，采用工程优化方法结合实验实现支架结构优化设计。建立考虑非局部效应的聚合物材料Cosserat连续介质模型，分析聚合物材料力学性能在降解过程中的演化机理，揭示聚合物血管支架服役过程中力学行为演化规律；采用改进的kriging代理模型工程优化方法结合实验研究，研制力学性能及其演化规律满足各阶段医学要求的聚合物血管支架。项目研究的理论成果、技术实现方法对丰富血管疾病介入治疗的理论和技术、推动心脑血管疾病微创介入治疗技术的发展具有重要的科学意义和实用价值。

中文关键词： 可降解聚合物；血管支架；力学性能；代理模型；多学科优化设计

英文摘要： The study of material degradation behavior and mechanical properties evolution mechanism of polymer stent is the basic research of polymer stent structural optimization. In order to solve the serious iatrogenic injury problem induced by current stents in the treatment process, a design of polymer biodegradable stent was proposed to match the stent’s mechanical property to the medical requirements for each stage. From the perspective of micromechanics, the mechanical behavior and its variation of polymer stent in the coupling effects of material degradation and structural were studied. Engineering optimization concept combining experimental was used for polymer stent structural design optimization. Cosserat continuum model for polymeric materials considering nonlocal effects is constructed. The mechanical properties of polymer and its evolution mechanism in the material degradation process were analyzed. The variation of mechanical properties of the polymer stent in the service process was disclosed. An optimal stent was designed to match the mechanical property to the medical requirements for each stage using kriging surrogate model-based engineering optimization method combining experimental. The theories and technical implementation of this project have important scientific significance and practical value of enriching the intervention theiry and techniques of cardiovascular disease minimally invasive treatment and promoting the development of its techniques.

英文关键词： Biodegradable Polymer;Stent;Mechanical Properties;Surrogate Model;Multidisciplinary Design Optimization