时序功能性血管支架与植入周围环境的相互作用与调控

项目名称： 时序功能性血管支架与植入周围环境的相互作用与调控

项目编号： No.81330031

项目类型： 重点项目

立项/批准年度： 2014

项目学科： 医药、卫生

项目作者： 黄楠

作者单位： 西南交通大学

项目金额： 290万元

中文摘要： 血管支架介入治疗尽管获得巨大成功，但仍难以避免并发症如再狭窄、晚期血栓、血管瘤、再发血管粥样硬化等的发生。可降解血管支架是最新发展，还存在降解周期过快（镁合金）、或过慢（高分子）、缺乏对血管支架与生物体环境的相互作用的调控措施等缺点。本研究基于现有研究与临床实践和申请者的研究基础，提出血管支架应具备调控与周围环境相互作用的时序功能性的新概念，提出可降解血管支架从介入血管至血管支架完全消失和完成血管重构的整个时序过程中与生物环境相互作用的调控的血管支架设计原则，充分考虑血管支架表面、药物、药物载体、血管支架材料等方面的作用，赋予血管支架抑制内膜增生、抗凝血、诱导内皮化、调控细胞构型、维护正常血管内膜、控制降解速率等时序多功能性，通过体外实验、血管粥样硬化模型动物进行血管支架与生物环境相互作用与调控研究，获得细胞与分子水平上的机理认识，为发展可再生性的新型血管支架奠定基础。

中文关键词： 血管支架;时序功能性;生物环境;相互作用;调控

英文摘要： Even if great success of the application of stent intervention, the complications such as restenosis, late thrombus, hemangiomas，atherosclerosis still can not be avoid. Absorbed stent is the recent development, however the drawbacks such as degradation is too fast (for Mg alloys) or too slow(for polymer), lack of controlling to the interaction between the stent and bio-environment. Based on the state of the art of the research and the clinic practices as well as the research foundations of the applier, a new conception is proposed that the stent should posses the time sequence functions which can play the role to control the interactions between the stent and the bio-environment in this project. A design philosophy that sufficient affects of stent surface, drugs, drug carrier, and stent base material should be taken into account to endow the stent the time sequence multifunction prohibiting intima hyperplasia, anticoagulation, inducing endothelialization, controlling configuration of the blood vessel cells, safeguarding health intima, controlling degradation of the stent. By means of in vitro and in vivo with the model of animal with atherosis blood vessel to investigate the interactions and the controlling factors of the stent with bio-environment, and reveal the mechanism in the level of cell and molecule . And provide the basics for developing regenerative new type of stent

英文关键词： stent ;time sequence functions;bio-enviroment;interaction;control