新型仿生自扩展可降解心血管医用植入材料的研究

项目名称： 新型仿生自扩展可降解心血管医用植入材料的研究

项目编号： No.51333005

项目类型： 重点项目

立项/批准年度： 2014

项目学科： 一般工业技术

项目作者： 计剑

作者单位： 浙江大学

项目金额： 300万元

中文摘要： 心血管疾病已成为人类的“第一杀手”。现代介入医用材料和器械使用，极大地丰富了心血管疾病的治疗手段。为根本解决心血管支架植入后中远期血栓和再狭窄问题，发展具有内皮愈合功能的全降解心血管植入器件成为关键。本项目针对全降解心血管植入器件制备和临床实现的关键问题，结合研究团队特色性的仿生界面理论和技术，发展NO量化控释技术和基于电纺的多元微纳调控技术，深入研究多元仿生结构调控血管内皮复杂体系竞争性生长的基本规律，为制备具有内皮再生功能的全降解心血管植入材料和器件奠定基础；并进一步针对全降解支架加工和临床植入的难题，探索采用多层不对称电纺技术制备具有湿度－温度双重响应形状记忆功能的新型心血管植入器件，为实现全降解聚合物支架的自扩展植入提供全新的途径。

中文关键词： 生物医用材料;生物降解高分子;心血管植入材料;仿生设计;一氧化氮

英文摘要： Cardiovascular disease is the leading causes of death worldwide. Percutaneous transluminal coronary angioplasty (PTCA), which is based on a non-degradable metal stent implantation, has been an important procedure in the treatment of cardiovascular diseases. However, in-stent thrombosis and restenosis are still significant concerns in its clinical application. A new type of biodegradable stent with good antithromboticity and anti- restenosis are believed to provide better alternative for metal stent implantation..Nitric oxide (NO) is well known as a potent anti-platelet agent and an effect inhibitor of smooth muscle cell (SMC) proliferation. The project will explore the possibility of fabrication of core-shell nanofiber via coaxial electrospinning as a new strategy to in-situ generates NO for cardiovascular application. A biodegradable biselenide polymer, which mimics glutathione peroxides (GPx) catalytic center to catalytic generating NO from endogenous donors, will be synthesized as the shell materials. Then the core-shell nanofiber of PCL based polymer will be fabricated via coaxial electrospinning. The shell will provide the biselenide(—SeSe—) GSH-Px mimic catalytic center to in-situ generate enough NO from endogenous donors for anti-thrombgenic. The core, which is the exogenous NO donors doped polymer, can be explored as a reservoir of the exogenous NO donors. The local delivery of exogenous NO donors, which combining with the endogenous donors, can be regulated to a suitable NO for SMCs inhibition and anti-restenonsis..Furthermore, taking the advantage of an electrospinning technique, a self-expanding implantation of cardiovascular stent will be explored via asymmetric electrospinning. The inner side of the stent is hydrophilic while the outer side of the stent is superhydrophobic. The effect of asymmetric structure to amplify the shape memory will be investigated and further explore the possibility of developing automatically self-expand stent after implantation due to the humido-responsive properties.

英文关键词： Biomedical Materials;Biodegradable Polymer;cardiovascular Biomaterials;Biomimic design; Nitric oxide