锥形血管中支架扩张耦合系统的力学行为与实验研究

项目名称： 锥形血管中支架扩张耦合系统的力学行为与实验研究

项目编号： No.51305171

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 机械、仪表工业

项目作者： 申祥

作者单位： 江苏大学

项目金额： 25万元

中文摘要： 基于申请者在血管支架的结构设计、力学性能分析以及实验测试等前期的工作基础，本课题将研究锥形血管中支架扩张耦合系统的力学行为与体外实验测试方法，探索血管的锥形特征对支架的扩张过程及结构设计的影响，为研制适用于锥形血管的高性能血管支架提供科学依据。具体而言：①将球囊、锥形血管壁、硬化斑块、支架作为一个非线性耦合系统，建立耦合系统的力学模型，研究用于模拟耦合系统的非线性有限元理论和数值模拟方法，为设计高性能的血管支架提供理论基础；②研究建立描述锥形血管中支架扩张耦合系统在扩张过程中涉及的血管损伤性、回弹性等力学行为的Kriging代理模型，建立支架扩张过程力学行为多目标优化模型，并探索相应的求解方法；③研究开发锥形血管中支架扩张耦合系统的体外实验测试装置，实现对支架扩张过程中涉及的血管损伤性、回弹性等力学性能的综合测量与分析，并为血管支架的优化设计和数值模拟分析提供实验验证。

中文关键词： 血管支架；锥形血管；耦合系统；力学行为；数值模拟

英文摘要： Applicants have studied the structure design of vascular stents, analysis and experimental testing of vascular stent mechanical properties, and so on. Based on the preliminary research, the project will investigate the mechanical behavior and in-vitro testing method of the stent expansion coupled system in tapered arteries. And effect of taper characteristics of tapered arteries on expansion process and structure design of stents is explored. The research fruits will provide a scientific basis for the development of good performance stent applied to tapered arteries. Specifically: ① Balloon, tapered vascular wall, plaque and stent are regarded as a nonlinear coupled system, and mechanical model of the coupled system is built. The non-linear finite element theory and the numerical simulation method used to simulate the coupled system are studied to provide a theoretical basis for designing good performance stents; ② The Kriging surrogate models of the vascular injury and the vascular recoiling involved in expansion process of stent are constructed. Then, a multi-objective optimization model of the mechanical behavior involved in the expansion process of stent is built, and the appropriate solution method is explored. ③ The in-vitro testing device of the stent expansion coupled system in tapered arteries is devel

英文关键词： vascular stents；tapered artery；coupled system；mechanical behavior；numerical simulation