针刺夹脊穴对糖尿病大鼠骨质疏松的作用及机制研究

项目名称： 针刺夹脊穴对糖尿病大鼠骨质疏松的作用及机制研究

项目编号： No.81202650

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 医学八处

项目作者： 程斌

作者单位： 山东中医药大学

项目金额： 23万元

中文摘要： 糖尿病性骨质疏松症随着近些年来糖尿病发病率逐年增高，且本病由于糖尿病患者的特殊机体状态，使伤残率和死亡率显著升高，给DM患者的生命健康造成极大威胁，也带来巨大的经济和社会负担。西医缺乏有效的治疗手段，我们通过长期临床观察发现针刺夹脊穴对治疗本病疗效稳定，本研究通过针刺夹脊穴观察其对DOP模型大鼠骨量、骨密度和骨形态的影响，与常规药物治疗疗效相比较，研究针刺夹脊穴对DOP的治疗作用，为临床针刺夹脊穴治疗DOP提供可靠的实验依据，同时为临床选穴提供依据；观察针刺夹脊穴对骨代谢相关活性物质表达的影响变化，初步探讨针刺夹脊穴治疗DOP的作用机理，为临床治疗DOP提供新的思路。

中文关键词： 针刺；夹脊穴；糖尿病性骨质疏松；机制；

英文摘要： With the recent years increasing diabetes rates，the incidence of Diabetic osteoporosis(DOP) increased year by year, and the disability and mortality rates of this disease increased significantly due to patients' body condition , posing a great threat to the life and health of patients with DM, also bringing huge economic and social burden. Western medicine lacks effective treatment for this disease. We found the stable efficacy of acupuncture Jiaji acupoints' in treating this disease through long-term clinical observation. This study observes the effects of acupuncture Jiaji on DOP rat model's bone mass, bone mineral density and bone morphogenetic compared with conventional drug treatment, to investigate the therapeutic effect of acupuncture Jiaji on DOP to provide reliable experimental basis for clinical acupuncture Jiaji treating DOP, also provide the basis for the clinical selection of points; By observing effects of acupuncture Jiaji 's impact in changing the expression of active substances of bone metabolism, this study elaborates the mechanism of acupuncture Jiaji in treating DOP, to provide new ideas for clinical treatment of DOP..

英文关键词： acupunture；JiaJi acupoint；diabete；osteoprasis；mechanism