超短脉冲微波热声极性分子成像及其应用基础研究

项目名称： 超短脉冲微波热声极性分子成像及其应用基础研究

项目编号： No.11304103

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 数理科学和化学

项目作者： 娄存广

作者单位： 河北大学

项目金额： 30万元

中文摘要： 热声成像特别是超短脉冲微波激发的热声成像是具有高分辨率、高穿透深度的新型无损成像技术，具有极高的研究价值和广阔的临床应用前景。本项目开创性的提出了基于内源性极性生物分子的无损微波热声分子成像技术。该技术根据部分生物分子具有较大的偶极矩和极化率而导致较强的微波吸收的原理，利用极性生物分子作为成像造影剂增强热声成像对比度，提高检测灵敏度。通过理论模型分析计算分子介电弛豫特性与微波峰值吸收频率的关系，优化波长及目标生物分子的选择。同时，结合生物分子具有可降解性及良好的生物相容性的特点，利用极性生物分子作为示踪剂，通过表面修饰实现分子靶向性，根据其在机体内病变组织处具有代谢异常及靶向聚集的特点，开展热声功能成像和早期疾病检测的基础研究。

中文关键词： 超短微波；热声成像；极性分子；石墨烯电极；穿戴智能设备

英文摘要： Thermoacoustic imaging in particular ultrashort microwave-induced thermoacoustic imaging is a noninvasive imaging technique with high resolution and high penetration depth, has a great value for scientific research and has broad clinical prospects. For the first time, this project proposed the method of endogenous biological molecules for noninvasive thermoacoustic imaging. This technique is based on the fact that a portion of polar biomolecules have large dipole moment and polarizability, which result in strong microwave absorption. These molecules can be used as a contrast agent to enhance the contrast of thermoacoustic imaging and improve the detection sensitivity. The peak frequency of microwave absorption of molecules could be obtained by the calculation and analysis of dielectric relaxation. Meanwhile, biological polar molecules has the character of good biocompatibility and is biodegradable, it is a good tracer for biomedical imaging. Diseased tissue of the body usually has a metabolic disorder, these polar molecules can also be modified to regulate their response to the biological environment and obtain the targeting character, and hence provide a feasible method for functional thermoacoustic imaging and early detection of diseases.

英文关键词： Ultrashort microwave；thermoacoustic imaging；polar molecular；graphene electrode；wearable intelligent device