甘草次酸受体介导的肝靶向给药系统的设计及制备

项目名称： 甘草次酸受体介导的肝靶向给药系统的设计及制备

项目编号： No.50873048

项目类型： 面上项目

立项/批准年度： 2009

项目学科： 生物科学

项目作者： 袁直

作者单位： 南开大学

项目金额： 35万元

中文摘要： 本申请拟采用受体介导设计，将具有高度肝靶向性、无毒、廉价的甘草次酸修饰到具有良好生物相容性及可生物降解性的天然高分子（如壳聚糖及其衍生物）和合成高分子（如聚氨基酸）载体上，并制成粒径窄分布的载药纳米粒子，研究材料的理化性能、细胞毒性、在小鼠体内分布及肝靶向性，旨在获得具有我国自主知识产权的新型肝靶向给药系统，实现在肝脏的高浓度积累，安全、稳定，缓释给药的目的，为早日实现临床应用提供理论指导和实践依据。

中文关键词： 甘草次酸；肝靶向；壳聚糖；聚氨基酸；缓释给药

英文摘要： The application relates to the field of a nano-scale liver targeting drug delivery system via receptor mediated. This system is composed by glycyrrhetinic acid-modified biodegradable and biocompatible polymers and loaded with anticancer drugs. The polymer matrix may include natural polysaccharides such as chitosan or its derivatives and synthetic polymers such as poly(amino acid). The nanoparticles with fairly narrow size distribution could be prepared based on the method of ion-crosslink, solvent dialysis or solvent evaporation. and some characters will be further investigated in detail with regard to the physicochemical properties, the in vitro cytotoxicity, the in vivo distribution in rats and the liver targeting ability. The main purpose of the application is to offer a novel liver targeting drug delivery system processing the properties of stable, secure and sustained-release for drugs, and provide theoretical guidance and practical basis for clinical application. We may hold promise for the effective achievement of liver targeting and the decrease of undesirable or life threatening side effects commonly exist in clinical anticancer therapy.

英文关键词： glycyrrhetinic acid; liver targeting; chitosan; poly(amino acid); sustained-release