刺激响应型超分子凝胶的设计组装及其药物控释研究

项目名称： 刺激响应型超分子凝胶的设计组装及其药物控释研究

项目编号： No.21301119

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 数理科学和化学

项目作者： 周义锋

作者单位： 上海应用技术学院

项目金额： 24万元

中文摘要： 通过功能小分子的自组装形成功能集成的超分子结构在开发新材料和新结构方面具有重要的科学意义和实用价值。作为一类自组装材料，小分子水凝胶因其结构易修饰、非价键自组装及微纳结构可控性决定其在药物缓释载体领域的广阔应用前景。本项目旨在通过分子设计和化学修饰设计合成一系列超分子有机凝胶因子，结合负药物分子的特定结构，在分子中引入适当的功能基团，调节分子内亲疏水基团的结构平衡，利用超分子自组装构筑适合抗生素负载的小分子凝胶材料。研究载药凝胶在体外模拟生物环境中对病灶部位温度和pH值等信号的可逆智能响应,并通过凝胶分子内特定基团监控药物缓释的动态过程，为设计合成具有刺激响应性的药物缓释凝胶材料提供理论依据和应用基础。本项目的开展不仅为设计合成凝胶因子和构筑结构性能可控有机纳米材料提供新的方法，也可促进有机凝胶在抗生素类药物载体方面的应用研究，在减少抗生素使用、保障人类身体健康等方面具有重要意义。

中文关键词： 有机凝胶；偶氮苯；自组装；光响应；氧化石墨烯

英文摘要： The self-assembling of small functional molecules into supramolecular structures is a powerful approach toward the development of new materials and new nanostructures. As a novel class of self-assembled materials, organogels have received considerable attention in recent years because their widely application prospects in the area of the drug controlled release for their easily modified structure, non-covalent intermolecular self-assembly and controllable micro-nano structures. This project aims to design and synthesize a series of organogelators by molecular design and chemical modification, combined with the specific structures of drug molecules, introduced appropriate functional groups to the gelator molecules, modulating the balance of hydrophilic and hydrophobic groups, constructed organogel materials suitble for loading of antibiotic drugs by supramolecular self-assembly. Further, we study on the reversible intelligent response prosess of the drug-loaded organogel to the site of lesion through the stimulation of heat or pH value in the modeling biological environment in vitro, monitor dynamic process of drug release through the specific signal groups in the gel, and provide the theory basis and application foundation as a guidance for design and synthesis with stimulus responsive drug release organogel mat

英文关键词： Organogel；Azobenzene；Self assembly；Light response；Graphene oxide