PLA2G7在前列腺癌中的表达和调控机制的研究

项目名称： PLA2G7在前列腺癌中的表达和调控机制的研究

项目编号： No.81201998

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 肿瘤学2

项目作者： 邵鹏飞

作者单位： 南京医科大学

项目金额： 23万元

中文摘要： PLA2G7是脂蛋白代谢和炎症反应通路中的重要因子，和心血管系统疾病的发生密切相关，近年来逐渐发现该因子和肿瘤的发生也有紧密相关。我们课题组在前期对前列腺癌手术的组织样本的研究发现，PLA2G7在前列腺癌肿瘤组织中的表达高于良性组织，且在高级别的肿瘤组织中表达更高。进一步研究发现PLA2G7的表达和TMPRSS2/ERG阳性的前列腺癌密切相关。本项目主要研究三个方面，PLA2G7和前列腺癌进展的关系，前列腺癌组织中PLA2G7表达和局部炎症反应的关系，PLA2G7和TMPRSS2/ERG相互影响和调控的关系。从而有可能在前列腺癌发病机制，分子分型方面提供新的依据，为临床诊断和个体化治疗发现新的可行途径。

中文关键词： 前列腺癌；侵袭性；炎症；调控机制；

英文摘要： PLA2G7 (phospholipase A2 group VII) is commonly known as lipoprotein-associated phospholipase A2 (Lp-PLA2) or plasma platelet activating factor acetylhydrolase (PAF-AH). PLA2G7 is an important mediator of inflammation and lipid metabolism. Elevated serum levels of Lp-PLA2 have been associated with increased cardiovascular risk in healthy populations and in patients with known vascular disease. Recently PLA2G7 has been found associated with formation and progression of malignant tumor. We have found that the expression of PLA2G7 in malignant tumor was elevated than the adjacent benign tumor through the tissue microarray analysis in paraffin embedded tissue from radical prostatectomy. In addition, higher mRNA levels were detected in high graded tumors than low/mediate tumors in the fresh prostate tissues. Furthermore in the DNA microarray analysis, we found a close relationship between PLA2G7 expression and TMPRSS2/ERG positivity. Based on the literatures and our previous studies, we plan to carry out our research on three aspects. Firstly, we plan to study the effect of PLA2G7 on the proliferation, adhesion, invasion and apoptosis of tumor cells through RNAi technique. Secondly, due to the PLA2G7 was found to relate with inflammation. We plan to study the extent of inflammation of prostate cancer tissue and corre

英文关键词： prostate cancer；invasion；inflammation；modulation mechanism；