伤害厌恶对道德判断的影响及其神经机制

项目名称： 伤害厌恶对道德判断的影响及其神经机制

项目编号： No.31300925

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 医药、卫生

项目作者： 胡盼盼

作者单位： 安徽医科大学

项目金额： 27万元

中文摘要： 道德判断是指对个人行为及特征是否与社会普遍接受的准则或价值观相符的判断。道德判断深入社会各个层面，长久以来的研究仅关注于环境、社会、文化等因素对其的影响。随着近年社会神经科学的研究发现厌恶情绪在道德判断中发挥了重要的作用。伤害厌恶作为道德感的核心其加工涉及到VMPFC、岛叶和前颞叶等脑区功能。然而伤害厌恶对道德判断影响的确切神经机制目前尚不清楚。本研究结合神经心理学、电生理学方法和静息态磁共振功能连接技术，试图通过对局灶性脑损伤患者系统的神经心理学研究，反社会人格特质群体脑网络功能连接研究，以及SSRI类药物干预道德判断神经机制的研究，检验VMPFC、岛叶和前颞叶在伤害厌恶加工及道德判断中的具体功能，揭示三个脑区间网络连接的方式，探讨SSRI类药物对道德判断能力的干预机制，进而促进道德判断能力和社会功能受损个体的诊断和康复治疗水平的提高。

中文关键词： 道德判断；社会认知；神经递质；神经环路；

英文摘要： Moral judgment refers to the judgement that decides whether the personal behavior and characteristics are compatible with the universally accepted norms and social values. Moral judgment penetrates deeply into all levels of society. Studies focused on the factors of influencing moral judgement have limited in the angles of environment, social and culture aspects. With the development of social neuroscience in recent years, studies revealed the crucial role of disgust in moral judgment. Harm aversion is one of the core elements in morality with the supports from broad brain regions including VMPFC, insular and anterior temporal cortex. However, the exact neural mechanism of harm aversion in moral judgment is still unclear.The present project combine neuropsychological methods, electrophysiological approach, functional connectivity analysis with purposes of testifing detailed functions of brain regions involved in harm aversion and moral judgement, revealing the difference of connectivity patterns between antisocial personality trait and healthy subjects and exploring the drug effects of SSRI in promoting moral judgement and prosocial behaviors. Finally, results from this project can enhance the level of diagnosis and rehabilitation in individuals with moral judgement impairments or social cognition dysfunction.

英文关键词： moral judgment；social cognition；neurotransmitter；neural circuit；