膳食营养和代谢组学与血压关系的队列研究

项目名称： 膳食营养和代谢组学与血压关系的队列研究

项目编号： No.81473044

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 武阳丰

作者单位： 北京大学

项目金额： 70万元

中文摘要： 膳食营养因素是导致高血压发生的重要原因，但需要进一步阐明膳食结构中何种宏量/微量营养素/食物/膳食模式导致了高血压的发生发展，且膳食因素是如何导致高血压的发生发展也缺乏相关科学数据支持。本项研究通过前瞻性随访宏量及微量营养素摄入与血压关系的国际协作研究（INTERMAP）中国的3个人群队列（北方：北京平谷，山西盂县；南方：广西武鸣），探讨膳食营养素的摄入与血压水平变化的因果关联，并引入代谢组学来对膳食摄入水平进行更为客观地测量，分析食物的摄入及其在体内代谢产生的代谢组与血压水平的关联，建立膳食与高血压发生的生理微观机制。数据收集包括标准化的血压测量（四次）、身高体重及腰围测量（两次）、24小时膳食调查（两次）、24小时尿液样本（两次）、空腹血液样本及心电图（各一次）、体力活动生活方式等混杂因素的问卷调查及致死性和非致死性心脑血管事件等，并以此分析膳食营养及代谢组对血压长期变化的影响。

中文关键词： 高血压；队列研究；代谢组学；膳食营养

英文摘要： Dietary factors are associated with unfavorable blood pressure (BP) levels, but what macronutrients/micronutrients/food/dietary pattern that could cause increased BP levels remain unclear, and the pathways of how dietary factors affecting BP are still unknown. A cohort study in three Chinese populations (North: Beijing, Shanxi; South: Guangxi) in the International Collaborative Study of Macronutrients, Micronutrients and Blood Pressure Study (INTERMAP) is proposed here to elucidate the causal relationship between dietary intake and blood pressure. Metabolomics approach will be used in this study to provide more objective measurement to dietary intake, to analyze food intake and its metabolites in relations to BP and to help achieve great understanding of etiopathogenetic pathways (mechanisms) whereby dietary factors affect BP in the human species. Data collection will include standardized BP measurement (4 times), height, weight and waist circumference measurement (2 times), 24 hour dietary recall collection (2 times), 24 hour urine collection (2 times), fast blood sample collection and electrocardiogram (1 time each), level of physical activity and other potential confounding factors by questionnaire, information of fatal and non-fatal cardiovascular events. Based on these data collections, the prospective relationship of dietary factors and metabolomics to follow-up BP and BP change trend will be analyzed.

英文关键词： adverse blood pressure;cohort study;metabolomics;nutrition