Fe3O4@PPy复合微球的制备及药物控释与靶向性能研究

项目名称： Fe3O4@PPy复合微球的制备及药物控释与靶向性能研究

项目编号： No.51303098

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 一般工业技术

项目作者： 沈腊珍

作者单位： 山西大同大学

项目金额： 25万元

中文摘要： 靶向药物治疗是未来治疗恶性肿瘤的发展方向，磁靶向药物输送系统是靶向治疗的有效途径。本项目提出将具有可逆掺杂/脱掺杂性能的导电聚吡咯（PPy）与Fe3O4磁纳米粒子复合作为药物载体，解决现有输送系统药物控释能力差的问题。系统优化超顺磁性Fe3O4纳米粒子的制备方法，探讨影响Fe3O4粒子的粒径、饱和磁化强度等的因素。以Fe3O4粒子为核，合成具有摇铃式中空结构的Fe3O4@PPy磁纳米复合微球。研究中间隔层的包覆与去除，揭示层与层之间的作用机理，分析中间隔层和表面活性剂的种类、工艺条件对复合微球的靶向性和可控释放性的影响规律。创新点在于：中空结构微球可以负载更多药物，并对Fe3O4的磁性影响较小；更重要的是，复合微球能够在掺杂/脱掺杂过程中完成对药物存储与释放的"开-关"作用，有效提高药物控释能力，能够实现靶向给药的高效、精准和灵敏性。这对未来实现靶向治疗的智能化和可控化有重要意义。

中文关键词： Fe3O4@PPy复合微球；超顺磁性；载药；靶向性；药物控释

英文摘要： Targeted drug therapy is the direction for the treatment of malignant tumor in the future. The magnetic targeted drug delivery system is an effective way for targeted therapy. In this program, a composite composed of conducting polypyrrole (PPy) with reversible doping-dedoping performance and Fe3O4 magnetic nanoparticles as drug carrier is proposed to improve the controlled release performance of existing drug delivery system. The preparation conditions of superparamagnetic Fe3O4 nanoparticles will be optimized systematically, and the factors affecting the size, saturation magnetization, and others of Fe3O4 nanoparticles will be investigated. With Fe3O4 particles as core, the nano Fe3O4@PPy hollow magnetic composite microspheres with bell shape will be synthesized. The coating and removal of interlayer will be studied to reveal action mechanism between the layers. The influence law of species of interlayer and surfactants, and technological conditions on targeting and controlled release of the composite microspheres will be analyzed. The main innovative point: the microspheres with a hollow structure can increase drug content and decrease the reduce degree of magnetic of Fe3O4 particles. More important, the composite microspheres can accomplish the switch function of controlled drug release with the doping-dedop

英文关键词： Fe3O4@PPy composite microspheres；superparamagnetism；drug loading；targeting；drug controlled release