项目名称: IL-6调控慢性非细菌性前列腺炎自噬的作用机制研究
项目编号: No.81500576
项目类型: 青年科学基金项目
立项/批准年度: 2016
项目学科: 医药、卫生
项目作者: 邰胜
作者单位: 安徽医科大学
项目金额: 18万元
中文摘要: 研究表明,细胞因子IL-6在慢性非细菌性前列腺炎(CNP)的发生、发展过程中起着重要的作用,但该细胞因子调控CNP的具体机制仍不十分清楚。同时相关研究表明,细胞自噬参与调控炎症的发生、发展;其可能机制是通过IL-6/STAT3信号通路及NLRP3炎症体。我们的前期研究结果表明IL-6可能参与调控CNP中自噬信号通路,因此IL-6调控CNP中自噬通路的机制是可能是通过STAT3信号通路和NLRP3炎症体。本项目拟在建立大鼠CNP模型的基础上,研究CNP中IL-6调控自噬通路、STAT3通路、NLRP3炎症体的相关作用;进一步研究CNP中IL-6对STAT3 信号通路调控、NLRP3炎症体对IL-6/STAT3信号通路的调控,阐明IL-6调控CNP中自噬通路的相关机制;发现其关键的调控位点和相关信号通路。对CNP发病机制提供新的理论依据,为CNP治疗及预防提供新的思路、新的作用靶点。
中文关键词: 慢性非细菌性前列腺炎;自噬;IL-6
英文摘要: It has been reported that the IL-6, a cytokine, plays a significant role in the chronic nonbacterial prostatitits (CNP), but its details of mechanism have been poorly understood. Certain studies also show the autophagy has an important effect on the inflammation, and its mechanism may be IL-6/STAT3 pathway and NLRP3 inflammasome. We have illustrated IL-6 may regulate autophagic pathway among CNP, among which the STAT3 pathway and NLRP3 inflammasome may play certain roles. This research aims to study the correlation of the IL-6 and autophagic pathway, STAT3 pathway, NLRP3 inflammasome; explore how IL-6 regulates STAT3 pathway and NLRP3 inflammasome regulates IL-6/STAT3 pathway; explain the mechanism regarding IL-6 effect on autophagy and demonstrate the key molecule and pathway. These results may reveal the seminal CNP’s pathogenesis, and provide the novel strategies for CNP’s treatment and prevention.
英文关键词: chronic nonbacterial prostatitis;autophagy;IL-6