从肝论治针刺调节围绝经期失眠情绪中枢整合效应研究

项目名称： 从肝论治针刺调节围绝经期失眠情绪中枢整合效应研究

项目编号： No.81503670

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 医药、卫生

项目作者： 王政研

作者单位： 四川省中西医结合医院

项目金额： 18万元

中文摘要： 临床上围绝经期失眠和情绪障碍密切相关。调查显示焦虑、抑郁等负性情绪是影响围绝经期失眠的主要原因。前期研究证实从肝论治针刺对失眠疗效显著且改善情绪障碍优势明显，但其中枢机制尚未明确。相关研究显示情绪中枢与睡眠机制密切相关，并且失眠患者的情绪环路存在神经功能异常。因此，本项目以围绝经期失眠患者为研究对象，以情绪中枢环路的神经功能变化为切入点，应用fMRI技术结合睡眠监测分析方法，研究针刺持续积累效应作用于机体后，在情绪中枢的调节作用下，脑神经信号在情绪神经环路得到整合并进一步产生应答后的变化特征，旨在揭示从肝论治针刺调节围绝经期失眠的情绪中枢整合效应机制，从神经影像学角度为从肝论治针刺治疗围绝经期失眠提供可视化的理论依据。

中文关键词： 围绝经期失眠；针刺；整合效应；情绪中枢；从肝论治

英文摘要： Primary insomnia and mood disorder are closely related.Surveys revealed that perimenopausal insomnia is mostly affected by negative emotion such as anxiety, depression,etc. Our recent research indicates that acupuncture has curative effect on primary insomnia by treating from liver,and has obvious advantages on mood disorders. But the specific mechanism is unclear.Studies have shown that emotional center and sleep mechanism are strongly coupled. The evidence also indicates that there has abnormal neural function of brain emotion circuit of insomnia patients. This project based on treating perimenopausal insomnia patient,study on the analyzing the neural functional variety such as connection between the amygdala and the important encephalic regions of emotion circuit,apply the fMRI techniques and sleep monitor methods,research the variation characteristics of cranial neural signal which is integrated at emotion circuit and has response.The variation is under the control of cortical area after the accumulative continued effects of acupuncture to the body. Aim to reveal the integrated mechanism of emotional center of treating perimenopausal insomnia from liver by acupuncture，and provide visual theory basis from neuroimaging aspect.

英文关键词： Perimenopausal Insomnia ; Acupuncture;Integrative Effect;Emotional Center ; Treating from Liver