The Gatenby-Gawlinski model for cancer invasion is object of analysis in order to investigate the mathematical framework behind the model working by means of suitable reductions. We perform numerical simulations to study the sharpness/smoothness of the traveling fronts starting from a brief overview about the full model and proceed by examining the case of a two-equations-based and one-equation-based reduction. We exploit a numerical strategy depending on a finite volume approximation and employ a space-averaged wave speed estimate to quantitatively approach the traveling waves phenomenon. Concerning the one equation-based model, we propose a reduction framed within the degenerate reaction-diffusion equations field, which proves to be effective in order to qualitatively recover the typical trends arising from the Gatenby-Gawlinski model. Finally, we carry out some numerical tests in a specific case where the analytical solution is available.
翻译:Gatenby-Gawlinski癌症入侵模型是分析的对象,目的是调查模型的数学框架,以适当的削减方式开展工作。我们进行数字模拟,从对全模型的简要概述开始,研究旅行前线的锐度/移动性,并着手审查基于两个等分和基于单一等分的削减情况。我们利用一个取决于数量有限近似的数字战略,并使用一个空间平均波速估计值来定量处理旅行波现象。关于一个基于方程式的模式,我们提议在退化的反应扩散方程式字段内进行缩减,事实证明这种做法行之有效,以便从质量上恢复Gatenby-Gawlinski模型产生的典型趋势。最后,我们在有分析解决方案的具体情况下进行一些数字测试。