The residualization procedure has been applied in many different fields to estimate models with multicollinearity. However, there exists a lack of understanding of this methodology and some authors discourage its use. This paper aims to contribute to a better understanding of the residualization procedure to promote an adequate application and interpretation of it among statistics and data sciences. We highlight its interesting potential application, not only to mitigate multicollinearity but also when the study is oriented to the analysis of the isolated effect of independent variables. The relation between the residualization methodology and the Frisch-Waugh-Lovell (FWL) theorem is also analyzed, concluding that, although both provide the same estimations, the interpretation of the estimated coefficients is different. These different interpretations justify the application of the residualization methodology regardless of the FWL theorem. A real data example is presented for a better illustration of the contribution of this paper.
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