A novel confidence interval estimator is proposed for the risk difference in noninferiority binomial trials. The confidence interval is consistent with an exact unconditional test that preserves the type-I error, and has improved power, particularly for smaller sample sizes, compared to the confidence interval by Chan & Zhang (1999). The improved performance of the proposed confidence interval is theoretically justified and demonstrated with simulations and examples. An R package is also distributed that implements the proposed methods along with other confidence interval estimators.
翻译:提出了一个新的信任间隔估计值,用于非急性二感试验的风险差异。信任间隔与准确的无条件测试相一致,该测试保留了第一类错误,并且比陈张和张(1999年)的置信间隔提高了能力,特别是较较小的样本体积。拟议置信间隔的改进在理论上是有道理的,并用模拟和实例加以示范。还分发了一套R软件,与其他信任间隔估计器一起实施拟议方法。