We define the non-commutative multiple bi-orthogonal polynomial systems, which simultaneously generalize the concepts of multiple orthogonality, matrix orthogonal polynomials and of the bi-orthogonality. We present quasideterminantal expressions for such polynomial systems in terms of formal bi-moments. The normalization functions for such monic polynomials satisfy the non-commutative Hirota equations, while the polynomials provide solution of the corresponding linear system. This shows, in particular, that our polynomial systems form a part of the theory of integrable systems. We study also a specialization of the problem to non-commutative multiple orthogonal polynomials, what results in the corresponding Hankel-type quasideterminantal expressions in terms of the moments. Moreover, such a reduction allows to introduce in a standard way the discrete-time variable and gives rise to an integrable system which is non-commutative version of the multidimensional discrete-time Toda equations.
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