We consider several mathematical issues regarding models that simulate forces exerted by cells. Since the size of cells is much smaller than the size of the domain of computation, one often considers point forces, modelled by Dirac Delta distributions on boundary segments of cells. In the current paper, we treat forces that are directed normal to the cell boundary and that are directed toward the cell centre. Since it can be shown that there exists no smooth solution, at least not in $H^1$ for solutions to the governing momentum balance equation, we analyse the convergence and quality of the approximation. Furthermore, the expected finite element problems that we get necessitate scrutinizing alternative model formulations, such as the use of smoothed Dirac distributions, or the so-called smoothed particle approach as well as the so-called 'hole' approach where cellular forces are modelled through the use of (natural) boundary conditions. In this paper, we investigate and attempt to quantify the conditions for consistency between the various approaches. This has resulted in error analyses in the $H^1$-norm of the numerical solution based on Galerkin principles that entail Lagrangian basis functions. The paper also addresses well-posedness in terms of existence and uniqueness. The current analysis has been performed for the linear steady-state (hence neglecting inertia and damping) momentum equations under the assumption of Hooke's law.
翻译:我们考虑一些模拟细胞所施加力量模型的数学问题。 由于细胞大小远小于计算范围, 人们常常会考虑点力, 以Dirac Delta 分布模式为模型, 在细胞的边界段上进行点力。 在本文中, 我们处理正常的细胞边界力量, 并且将细胞中心作为模型。 由于可以证明不存在平稳的解决方案, 至少不是以1美元来计算调节动力平衡方程式的解决方案, 我们分析近似值的趋同和质量。 此外, 我们得到的预期有限元素问题需要仔细分析替代模型的配方, 如使用平滑的Dirac分布, 或所谓的平滑的粒子方法, 以及所谓的“洞”方法, 细胞力量通过使用( 自然) 边界条件来模拟。 由于可以证明不存在任何平稳的解决方案, 我们调查并试图量化各种方法之间一致性的条件。 这导致在基于Galerkin 原则的数值解决方案中进行错误分析, 包括拉格兰基函数。 纸色的分布式分布式分布法则以所谓的“ ” 以及所谓的“洞洞穴”, 以及所谓的“ 模型分析也以稳定的“ 状态”, 的“ 分析以稳定的“ 的轨态” 和“ 的轨平态” 。