The global pandemic of the 2019-nCov requires the evaluation of policy interventions to mitigate future social and economic costs of quarantine measures worldwide. We propose an epidemiological model for forecasting and policy evaluation which incorporates new data in real-time through variational data assimilation. We analyze and discuss infection rates in China, the US and Italy. In particular, we develop a custom compartmental SIR model fit to variables related to the epidemic in Chinese cities, named SITR model. We compare and discuss model results which conducts updates as new observations become available. A hybrid data assimilation approach is applied to make results robust to initial conditions. We use the model to do inference on infection numbers as well as parameters such as the disease transmissibility rate or the rate of recovery. The parameterisation of the model is parsimonious and extendable, allowing for the incorporation of additional data and parameters of interest. This allows for scalability and the extension of the model to other locations or the adaption of novel data sources.
翻译:2019-nCov的全球流行病要求对政策干预进行评估,以降低今后全世界检疫措施的社会和经济成本。我们提出预测和政策评估的流行病学模式,通过变异数据同化纳入实时新数据。我们分析和讨论中国、美国和意大利的感染率。特别是,我们开发了适合中国城市与该流行病相关的变量的定制区划SIR模式,名为SITR模式。我们比较和讨论模型结果,这些模型的结果随着新的观察结果的出现进行更新。采用混合数据同化方法,使结果对初始条件产生稳健效果。我们使用该模型来推断感染人数以及疾病传染率或恢复率等参数。模型的参数比较性是均衡的,可以扩展,允许纳入更多的数据和相关参数。这样可以使模型可扩缩,并推广到其他地点,或者调整新的数据来源。