Due to the lack of effective mpox detection tools, the mpox virus continues to spread worldwide and has once again been declared a public health emergency of international concern by the World Health Organization. Deep learning-based mpox detection tools are crucial to alleviate mpox outbreak. However, existing methods have difficulty in achieving a good trade-off between detection performance, parameter size, and model complexity, which is crucial for practical applications and widespread deployment, especially in resource-limited scenarios. Given that the success of Mamba in modeling long-range dependencies and its linear complexity, we proposed a lightweight hybrid architecture called MpoxMamba. MpoxMamba utilizes deep separable convolutions to extract local feature representations in mpox skin lesions, and greatly enhances the model's ability to model the global contextual information by grouped Mamba modules. Experimental results on two widely recognized mpox datasets demonstrate that MpoxMamba outperforms existing mpox detection methods and state-of-the-art lightweight models. We also developed a web-based online application to provide free mpox detection services to the public in the epidemic areas (http://5227i971s5.goho.co:30290). The source codes of MpoxMamba are available at https://github.com/YubiaoYue/MpoxMamba.
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