基于低温雨雪冰冻模拟环境的运动生理响应及其适应调控物质筛选研究

项目名称： 基于低温雨雪冰冻模拟环境的运动生理响应及其适应调控物质筛选研究

项目编号： No.41275159

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 天文学、地球科学

项目作者： 安玉香

作者单位： 沈阳师范大学

项目金额： 40万元

中文摘要： 低温雨雪冰冻是近年严重威胁人类生存的全球性重大气候灾害，人体对冰雪灾害的生理响应（特别是运动生理响应）是医学气象预报和救灾防护亟需的基础数据，这些基础资料的缺乏是严重制约医学气象预报发展的瓶颈问题。人体对冰雪灾害的脆弱性将随气候变暖和生活舒适化进一步凸显，对外源性适应调控物质的需求亦增大。本项目基于低温雨雪冰冻灾害的气候特征确定模拟环境的气候因子，并以温湿度指数与运动响应相关性为切入点，利用运动生理学研究手段观察小鼠对人工模拟环境的运动生理响应，采用分子生物化学、原位末端标记、免疫组化技术对内源性应激调控物质进行定量定位分析，据此筛选外源性适应调控物质，并对低温雨雪冰冻灾害干预时机的选择提供依据。本研究可为低温雨雪冰冻天气过程运动生理响应及其适应机制提供基础数据，为低温雨雪冰冻灾害的医学气候预报和气候应激保护剂筛选提供关键参数，进而为相关气候受灾人员体能预测和救灾人员科学防护提供参考依据。

中文关键词： 低温雨雪冰冻灾害；运动生理响应；室内模拟装置；模拟环境；暴露主体

英文摘要： Abstract: Cryogenic Freezing Rain and Snow weather is a powerful global climate disaster that threatens human beings' survives seriously in recent years. The physiological response(especially Exercise physiological response) of human beings toward disaster of ice and snow is a basic data including medical meteorological forecast and relief protection, which is bottleneck problem that seriously restricts the development of medical meteorological forecast due to its shortage .With the climate warming and life being comfortable， the vulnerability of human beings toward the disaster of ice and snow will become sharper, what's more, the demanding of exogenous adaptation regulation substances will enlarge accordingly. This project determines climatic factors of imitation environment based on the features of climate of cryogenic freezing rain and snow weather disaster. In addition, this paper set the correlation between temperature-humidity index and motion response as breakthrough point, using the research means of sports physiology to observe the exercise physiological response that mice are influenced by artificial imitation environment. Moreover, this project uses molecular biochemistry, in situ end labeling and immunohistochemical technique to make a quantitative orientation analysis about endogenous stress regu

英文关键词： cryogenic; rain-snow and frozen disaster；sports physiological response；indoor simulation apparatus；simulation environment；exposed bodies