基于金纳米棒和上转换纳米晶的多功能纳米复合材料构建与性能研究

项目名称： 基于金纳米棒和上转换纳米晶的多功能纳米复合材料构建与性能研究

项目编号： No.11204122

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 物理学I

项目作者： 赵军伟

作者单位： 洛阳理工学院

项目金额： 28万元

中文摘要： 针对亟待研发出能用于癌症等重大疾病早期诊断和无创地准确定位与治疗的新型纳米复合材料的重大需求，本项目计划以金纳米棒（GNRs）为核，二氧化硅（SiO2）为隔离层，上转换纳米晶（UPNCs）为壳构建多功能纳米复合材料。制备的纳米复合材料将UPNCs在生物标记和成像方面应用的独特优势与GNRs通过表面等离子体共振(SPR)吸收近红外光产生热疗效应的特性结合起来。重点研究在SiO2包覆的GNRs表面生长UPNCs的生长动力学过程，UPNCs与GNRs之间的通过SPR或荧光共振能量传递（FRET）相互作用的规律和作为核材料的GNRs的光热转换效率，以获得具有最佳结构和性能的多功能纳米复合材料。通过开展细胞标记成像和热疗效应的初步实验研究，验证纳米复合材料在癌症诊疗方面的可行性。为癌症等重大疾病的早期诊断和治疗提供科学基础和理论依据。

中文关键词： 金纳米棒；上转换纳米晶体；纳米复合材料；多功能；生物医学

英文摘要： Aiming at the significant demand and the urgent development of the novel nanocomposites which can be utilized for the early diagnosis, noninvasive accurate position and the treatment of cancer or other serious diseases, the project will plan to use gold nanorods (GNRs) as core, SiO2 as isolation layer and upconversion nanocrystals (UPNCs) as shell to construct multifunctional nanocomposites.The obtained nanocomposites will combine the unique advantages of UPNCs which can be used in biological labeling and imaging with the unique advantages of GNRs which can absorb near infrared light by surface plasmon resonance (SPR) to produce photothermal conversion effect. To obtain optimum structure and properties of multifunctional nanocomposites, the research interests focus on the crystal growth kinetics of UPNCs on the surface of SiO2 coating GNRs, the SPR or fluorescence resonance energy transfer (FRET) interaction between UPNCs and GNRs and the photothermal conversion efficiency of GNRs as core. To validate their feasibility for the cancer-related applications,the preliminary experiments of cellular labeling and imaging and photo-thermal therapy will be performed. The results obtained from this project may provide new scientific and theoretical insights for the early diagnosis and therapy of cancer and other serious

英文关键词： gold nanorods；upconversion nanocrystals；nanocomposites；multifunction；biomedicine