基于同步辐射红外光源的三维红外谱学显微CT技术及其应用

项目名称： 基于同步辐射红外光源的三维红外谱学显微CT技术及其应用

项目编号： No.11475252

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 数理科学和化学

项目作者： 陈敏

作者单位： 中国科学院上海应用物理研究所

项目金额： 98万元

中文摘要： 同步辐射红外光源具有光源点尺寸小，高准直性，高亮度的特点，把它作为红外显微镜的光源可以轻松地聚焦到衍射极限，在高信噪比的基础上实现微米的空间分辨，极大的提高实验数据采集的效率和质量。相比于二维红外谱学显微技术，三维红外谱学CT技术可以得到更多的样品内部信息，如样品组分的三维空间分布，有助于更深入的了解其微观物理、化学等机理，并且无需对样品进行染色或做标签。本项目拟发展基于同步辐射光源的三维红外谱学显微CT技术，空间分辨率达到衍射极限，提供样品红外光谱信息的三维空间分布，获得分子水平的生物化学、物理等信息。为提高实验效率，将信号处理中的压缩感知技术应用到红外谱学显微CT技术中，以减小重构所需的投影数。本项目一旦建成，将为国内外红外用户提供一个高性能的基于上海光源同步辐射红外光源的实验平台。

中文关键词： 同步辐射；红外谱学显微；CT成像

英文摘要： Infrared beamline of SSRF provides IR light that is much higher brighter than standard laboratory IR sources, allowing the spectroscopic study of molecules with much higher precision and sensitivity. The improvement in spatial resolution and in spectral quality to the diffraction limit has led to a plethora of applications that is just being realized. Compared with 2D infrared spectromicroscopy, 3D Synchrotron infrared spectromicroroscopy will provide more details of the sample, for instance, the 3D spatial distribution of the different components of the sample. In this project, a novel non-destructive 3D infrared spectromicroscopy using Synchrotron Radiation source will be developed that provides molecular-level chemical/physical information of unprecedented detail on biological and other specimens with no need to stain or alter the specimen. In order to reduce the required projection number of the specimens sharply, Compressed Sensing theory will be improved to put into the 3D image reconstrusction process. This system will become a powful experimental platform for infrared users to obtain more details on biological and other specimens.

英文关键词： Synchrotron radiation;infrared spectromicroscopy;CT imaging