单颗粒金属纳米结构的高通量宽场成像光谱表征技术研究

项目名称： 单颗粒金属纳米结构的高通量宽场成像光谱表征技术研究

项目编号： No.21303152

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 数理科学和化学

项目作者： 李剑平

作者单位： 中国科学院深圳先进技术研究院

项目金额： 26万元

中文摘要： 单颗粒局域表面等离子体共振(SP-LSPR)散射谱表征是研究金属纳米结构表面/界面物理化学性质和实现SP-LSPR生化传感的重要分析技术。然而目前主流的暗场显微摄谱法是一种串行表征方法，其空间和光谱信息同时获取能力及检测通量均十分有限。本课题在前期工作的基础上，拟采用成像傅里叶变换光谱技术原理，结合暗场显微照明，发展一种宽场成像光谱测量技术，以提升传统表征方法的不足。通过仪器研制和测试，实现一部可同时测得宽视场中每一像素处光谱的暗场成像傅里叶光谱仪原型机；通过应用实验研究，探索和展示该原型机应用于高通量SP-LSPR散射谱表征的可行性；最终建立基于暗场成像傅里叶光谱技术的高通量金属纳米结构SP-LSPR散射谱表征方法。本课题的实施可为纳米科学的基础研究提供一种新型的单颗粒表面/界面物理化学表征技术，对基于单个微纳结构光谱分析的生物传感、药物筛选以及环境监测等高技术应用实现亦具有重要的价值。

中文关键词： 单颗粒；金属纳米结构；高通量；局域表面等离子体共振；成像光谱

英文摘要： Single-particle localized surface plasmon resonance (SP-LSPR) scattering spectral characterization is an important analytical technology for studying physical and chemical properties of metallic nanostructures at their surfaces/interfaces and SP-LSPR biochemical sensing realization. However, present dominant method of using dark-field microscopy and imaging spectrograph in conjunction is a type of serial characterization method, which has very limited power in acquiring spatial and spectral information and very low detection throughput. On the basis of previous research, the project plans to adopt the principle of imaging Fourier transform spectroscopy and combines it with dark-field microscopic illumination to develop a wide-field imaging spectroscopy technology for improving the afoementioned defficiencies of traditional characterization method. Through the study of instrumentation setup and performance testing, a dark-field imaging Fourier spectrometer prototype that can obtain spectrum at every pixle from a wide filed is expected to set up. Through the application experiment research, the feasibility of applying this prototye for SP-LSPR scattering spectral characterization is to be explored and demonstrated. Finally, the methodology that based on this high-resolution dark-field imaging Fourier spectroscopy

英文关键词： Single-particle；Metallic Nanostructure；High-throughput；LSPR；Imaging Spectroscopy