金刚石–有机聚合物杂化离子色谱固定相的研制及应用

项目名称： 金刚石–有机聚合物杂化离子色谱固定相的研制及应用

项目编号： No.51503182

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 一般工业技术

项目作者： 黄忠平

作者单位： 浙江工业大学

项目金额： 20万元

中文摘要： 人造金刚石具有机械强度大，化学稳定性强，有机溶剂兼容性好等优点，可作为超高效离子色谱固定相的潜在基质。但金刚石的惰性表面不易于直接功能化修饰，并且颗粒的不规则或不均匀严重影响色谱分离柱效，因此不适合直接作为色谱固定相基质。本项目为克服金刚石作为色谱固定相基质存在的不足及市售有机聚合物基质固定相不耐超高压的缺点，拟通过包覆、掺杂等方式制备球形金刚石–有机聚合物杂化基质。利用金刚石独特的物理化学特性，提高基质微球的机械强度；并且球形基质的使用有利于提高色谱固定相的柱效；最后对基质微球进行功能化修饰，研制开发超高效离子色谱固定相。该固定相不仅具有传统有机聚合物基质固定相耐酸碱性强的优点，同时兼具硅胶基质固定相柱效高、耐超高压的特点，从而实现目标离子在超高压条件下的快速、高效分离。此外，将探索金刚石–有机聚合物杂化基质固定相在超高压条件下的色谱性能变化，并应用于复杂基质样品及多组分样品的分析检测。

中文关键词： 人造金刚石；有机聚合物；杂化；固定相；离子色谱

英文摘要： Synthetic diamond combines mechanical stability, chemical inertness and absence of shrinking or swelling in the presence of inorganic or organic solvents. Therefore, it could be applied as the potential substrate of chromatographic stationary phase in ultra performance ion chromatography. However, direct utilization of synthetic diamond as the substrate of ion chromatographic stationary phase is still not available, due to the difficulty of modifying the inert diamond surface and severe chromatographic band broadening causing by irregular and nonuniform diamond shape. To overcome the shortages of diamond as the chromatographic stationary phase substrate and that commercial polymer–based stationary phase is fragile at condition of ultra–high pressure, an approach to prepare novel diamond–organic polymer hybrid stationary phases is proposed by cladding or embedding. With the advantages of diamond, mechanical strength of the hybrid substrate would be improved. After the functional modification of the hybrid substrate, high column efficiency is available by the employment of spherical stationary phase. The novel hybrid stationary phase could be operated at a wide pH range (~pH 0–14) as the traditional polymer–based stationary phase, and especially under ultra-high pressure as the silica–based stationary phases, making ultra performance ion chromatography possible with short analytic time and high efficient separation. Additionally, the investigation of chromatographic parameters of novel hybrid stationary phase under ultra–high pressure would be performed. Finally, the optimized hybrid stationary phase and separation conditions would be applied to the analysis of samples with complex matrix or multi components.

英文关键词： Synthetic diamond;Organic polymer;Hybrid;Stationary phase;Ion chromatography