针灸“四关穴”对阿尔茨海默病的脑功能网络调节机制研究

项目名称： 针灸“四关穴”对阿尔茨海默病的脑功能网络调节机制研究

项目编号： No.81471649

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 李坤成

作者单位： 首都医科大学

项目金额： 73万元

中文摘要： 阿尔茨海默病（AD）是近年来倍受关注的脑重大疾病之一，失连接综合症是导致AD认知功能下降的重要发病机制，动物实验和临床观察表明，针灸可通过直接调整神经通路产生治疗效应，但其机制仍不清楚。本课题拟通过静息态功能磁共振成像方法，并综合针灸学和神经科学，进行多模态数据融合分析，通过比较针灸四关穴治疗前后AD的脑功能连接以及脑网络参数改变，及其与神经心理学测量的相关性分析，阐明早期AD的针灸治疗机制，从功能连接角度为针灸治疗AD提供理论依据，并为临床早期AD治疗筛选有效穴位，客观评价针灸治疗AD的效果。

中文关键词： 针灸；功能磁共振成像；阿尔茨海默病

英文摘要： Alzheimer's disease (AD) is one of the major brain diseases which received more attention in recent years. The disconnection syndrome is the main pathophysiological mechanism leading to cognitive decline in AD patients. Both animal experiment and clinical observation have demonstrated that acupuncture can generate treatment effect on AD patients by moderating the neural pathway directly. However, the underlying mechanism remains unclear. By using resting state functional magnetic resonance imaging (fMRI) method, as well as acupuncture and neurology sciences, we will explore the multi-modality data analysis; compare brain connectivity and network parameters changes between pre- and post-acupuncture treatment; analyze the correlation between fMRI changes and neuropsychology test. The present study aims to elucidate the neural mechanism of acupuncture therapy on early AD, provide theoretical evidence from the perspective of functional connectivity. And furthermore, the study will screen the effective acupoints and evaluate therapeutic effect for clinical acupuncture therapy on AD.

英文关键词： acupuncture;functional magnetic resonance imaging;Alzheimer's Disease