大动脉调转术改进几何构型对主动脉瓣关闭不全影响的生物力学机理和手术规划研究

项目名称： 大动脉调转术改进几何构型对主动脉瓣关闭不全影响的生物力学机理和手术规划研究

项目编号： No.11472023

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 数理科学和化学

项目作者： 乔爱科

作者单位： 北京工业大学

项目金额： 86万元

中文摘要： 根据临床医生的经验和设想，申请人提出了大动脉调转术几种改进几何构型的方案，但需要从原理上了解改进几何构型对术后主动脉瓣关闭不全的影响。本项目的主要科学问题就是大动脉调转术改进几何构型对主动脉瓣关闭功能影响的生物力学机理；研究目的就是为更好地解决大动脉调转手术中的临床医学问题提供科学依据。改进几何构型包括窦管交界直径锥度、冠状动脉切片大小、瓣叶开口与主动脉中心轴夹角大小、心室流腔形状等。本项目利用临床病例数据和影像资料，建立有限元分析模型并进行静态、动态和流固耦合数值模拟；制作离体模型完成PIV实验和主动脉瓣运动/力学测试实验，验证数值模拟结果；通过对多中心临床病例进行回顾性分析和随访观察，建立统计分析和神经网络算法，开发简单易用的手术规划系统。通过本项目的研究，有助于临床医生更加方便高效、科学合理、有依据地制定大动脉调转术的治疗方案，也可以为人工瓣膜和血管吻合器的设计和检验提供理论指

中文关键词： 有限元分析；血流动力学；心脏外科；手术规划；数值模拟

英文摘要： The applicant proposed several modified geometric configurations for Arterial Switch Operation (ASO) according to surgical experience and assumption of clinicians, while the mechanism needs to be investigated so as to know the postoperative influence of the modified geometric configurations for ASO on aortic insufficiency. The main scientific problem of the present project is the biomechanical mechanism of the influence of modified geometric configurations for ASO on aortic insufficiency. The research purpose is to provide the scientific basis for better solving the clinical problems in ASO. The modified geometric configurations include the diameter taper ratio of the sinotubular junction to the aortic annulus, the size of coronary artery root button, the angle between the aortic valve orifice and the ascending aortic axes, and the shape of left ventricular outflow tract, etc. The research contents include: establishing finite element models based on patient cases and imaging data; numerical simulation by using statics, dynamics and fluid-structure-interaction method; verifying simulation results by experimental method with PIV system and aortic valve movement/mechanics test instrument; analyzing multi-centric patient cases retrospectively and with follow-up observation, establishing statistical analysis and neural network algorithm, and developing easy-to-use surgical planning system. The research results may be used to guide the evidence-based surgical decision easily and scientifically, and offer the theoretical support for the design and test of prosthetic valve and vascular stapler device.

英文关键词： Finite element analysis;Hemodynamics;Cardiac surgery;Surgical planning;Numerical simulation