可示踪可激发体内双级递氧体系构建与评价

项目名称： 可示踪可激发体内双级递氧体系构建与评价

项目编号： No.81473146

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 胡一桥

作者单位： 南京大学

项目金额： 70万元

中文摘要： 多年来人们一直在寻找有效的手段来逆转人体的缺氧状态。缺氧会对器官和组织造成严重损伤，例如，大脑缺氧超过8分钟可造成脑死亡；人体器官缺氧会坏死，肿瘤部位缺氧会造成放化疗的失败。输血是目前逆转体内缺氧的唯一有效手段，但血液的保存时间仅40天，又存在较大的安全隐患。本研究拟以白蛋白、全氟化碳、近红外光敏剂为主要材料，采用蛋白质解折叠-折叠充氧方法，构建递氧能力强，且具备可示踪、可激发的双级递氧体系。并对其的全身性紧急递氧能力，以及目标区控制递氧能力进行评价及研究。希望为安全有效的逆转体内缺氧系统的研发提供新思路。

中文关键词： 氧载体；紧急递氧；全氟碳；示踪；多功能

英文摘要： For more years, people have been searching for effective methods to reverse the hypoxia state of human body. Hypoxia can cause serious damages to the organs and tissues. For example, brain cells starved for oxygen begin to die in eight minutes; body organs will be necrotic under hypoxia condition; hypoxic tumor cells are the main reasons for radiotherapy and chemotherapy treatment failure. Currently, it is well accepted that blood transfusion is the only effective measure to reverse the body hypoxia. However, blood can be stored for only forty days before use, and blood transfusion has many potential safety risks. In his study, we attempt to construct an in vivo two-stage oxygen delivery system using materials of albumin, perfluorocarbon and near-infrared photosensitizer, methods of protein unfolding/refolding oxygenation. This system provides high oxygen delivery capacity and multiple functions such as tracing and trigger. The systemic emergency oxygen delivery ability, and target regional oxygen controlled release ability will be explored and evaluated. We intend to provide a new strategy to develop safe and effective body hypoxia reverse system.

英文关键词： Oxygen carrier;emergency oxygen delivery;perfluorocarbon;tracing;multifunction