稀土配位超分子荧光探针的结构设计、构筑及其对小分子/离子的荧光检测

项目名称： 稀土配位超分子荧光探针的结构设计、构筑及其对小分子/离子的荧光检测

项目编号： No.51472275

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 一般工业技术

项目作者： 杨洋溢

作者单位： 中山大学

项目金额： 83万元

中文摘要： 小分子（含离子）在生物、医学、环境等领域扮演着重要的角色，对小分子离子的检测一直是科学研究的热点。目前，金属-有机框架（MOFs）用于检测小分子离子已获得相当关注。而具有特征光谱的稀土配位超分子（含稀土MOFs）应用于分子识别及荧光探针还未得到充分认识。本项目拟利用超分子化学理念，由分子识别及分子自组装入手，统筹考虑稀土配位超分子及其与客体小分子所构成的二级主客体超分子体系中分子内及分子间的能量吸收和传输效应，设计合成与稀土能级匹配的共轭天线配体，制备系列稀土配位超分子材料。通过增加弱作用点位，改变吸、推电子基团及辅助发色团，调节配体能级与稀土激发态能级的匹配度等，提高配位超分子对目标客体小分子的识别能力和稀土发光的敏感性，研究配位超分子空间结构、配位环境、功能基团等与客体分子的相互作用对稀土特征荧光的影响，探索此类稀土配位超分子材料对不同类型客体小分子的荧光响应规律。

中文关键词： 稀土配合物；稀土发光材料；荧光探针；晶体结构调控；薄膜

英文摘要： Small molecules/ions play a crucial role in the field of biology, medicine and environment, the detection of small molecular/ions has been a scientific focus.Currently, the research on metal-organic frameworks (MOFs) applied to small molecule sensing has attracted considerable attention; But the study on lanthanide coordination supramolecular (including Ln MOFs) for small molecules fluorescence detection have not been documented well, alrought lanthanide supramolecular has identified spectral fluorescence. This project intends to apply the concept of supramolecular chemistry, by using the molecular recognition and molecular self-assembly, consider overall the energy absorption and transmission effects of intermolecular and intramolecular, which come from the secondary systems of host-guest supramolecular and lanthanide coordination supramolecular, design and synthesize conjugated antenna ligands matching well with the lanthanide ions, and prepare series of lanthanide coordination supramolecular materials. By increasing the weak interaction sites, changing the electron absorption or donating groups and auxiliary chromophores, fitting the ligand energy level to match the lanthanide ion excited level, etc., to improve the recognition of coordination supramolecular to the target small molecules and lanthanide fluorescence sensitivity. Study the spatial structure of coordination supramolecular, coordination environment, functional groups, and their interaction to the guest molecule influcene on the fluorescence characteristics of the lanthanide ions, explore these lanthanide fluorescent supramolecular materials response to different types of small molecules. To achieve the structural design of new lanthanide fluorescent probes and provide an experimental basis and theoretical construct.

英文关键词： Lanthanide coordination supermolecular;lanthanide luminescent material;Fluorescent sensor;Crystal structure regulation;Thin film