TiO2纳米管/钛界面强化机制及其渐变管径的肽控释抗菌行为

项目名称： TiO2纳米管/钛界面强化机制及其渐变管径的肽控释抗菌行为

项目编号： No.51201129

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 金属材料学科

项目作者： 张兰

作者单位： 西安交通大学

项目金额： 25万元

中文摘要： 着眼于承力骨的修复与替换应用，针对传统阳极氧化TiO2纳米管层与钛合金基体之间弱界面结合对其承力的制约，立足于协调细胞成骨表达及抗菌肽长期释放与其高量负载对TiO2纳米管相反管径需求的矛盾，通过攻克氟离子沉降阳极氧化新技术，在钛合金表面设计并制备具有较高界面结合强度、管径呈渐变式外小内大的TiO2纳米管层。探索TiO2纳米管层/钛合金界面结合强度、界面结构、管径及层厚随氟离子沉降阳极氧化工艺参量之间的变化规律，揭示TiO2纳米管层与基体之间形成强界面结合的机制；研究纳米管管径及层厚对抗菌肽释放动力学的影响规律，及其抗菌行为的持续效应；揭示负载抗菌肽的纳米管管径与骨磷灰石诱导能力和成骨相关细胞附着及功能表达之间的关系，提出钛合金表面TiO2纳米管呈高结合强度、生物活性、长期高效抗菌的结构优化构建方案，为其满足临床应用奠定基础。

中文关键词： TiO2纳米管；渐变管径；界面；抗菌；控释

英文摘要： The poor adhesion of the traditionally anodized TiO2 nanotube layers on Ti substrates could significantly compromise their applications in load-bearing bone repair and replacement. TiO2 nanotube with small diamater is propitious to enhance cell osteogenesis expression and long-term release of loaded antimicrobial peptide, but the loading capacity of TiO2 nanotube layers can be increased by increasing the diamater of the tubular layers. Based on this conflict, we develop a new technology of anodization including sedimentation of F- during the process. A TiO2 nanotube layer with high adhesion strength and graded diameter can be prepared. The effect of anodization parameters on TiO2 nanotubes/Ti interfacial strength,interfacil structure, nanotube diamater and thickness will be explored. The mechanism of the strengthened interface formation of the TiO2 nanotube layer will be disclosed. The influence of nanotube diameter and thickness on the releasing kinetic and antimicrobial behavior of antimicrobial peptide will be studied. In addtion, after loading antimicrobial peptide,the relationship between the nanotube diameter and the abilities such as inducing bone-like apatite, cell adhesion and osteogenesis expression will be realized. In order to facilitate the TiO2 nanotube layer to be used in clinic, a project to

英文关键词： TiO2 nanotube；graded diamater；interface；antimicrobial；controlled released