防治动脉粥样硬化的中药：沙生蜡菊花降脂和抗炎活性成分的分析和鉴定

项目名称： 防治动脉粥样硬化的中药：沙生蜡菊花降脂和抗炎活性成分的分析和鉴定

项目编号： No.81202418

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 药物学、药理学

项目作者： 王立波

作者单位： 哈尔滨医科大学

项目金额： 23万元

中文摘要： 动脉粥样硬化(AS)严重危害人类健康，目前其治疗以西药为主，缺点是副作用大，不能治愈，长期服用对机体损害大。AS本质是脂质参与的炎症性病变，因此降脂和抗炎并用防治效果会更佳。中药副作用较小，筛选范围广，值得探讨，但目前还没有兼具降脂和抗炎功效的单味中药防治AS。C反应蛋白(CRP)是AS炎症反应中最强的炎性标记物，且CRP/CD32-NF-κB(p65)-VCAM-1通路参与炎症的发生发展，可促进AS形成。我们首次发现沙生蜡菊花降脂部位（HA）具有抗AS活性，并能降低CRP诱导的核转录因子NF-κB水平，这提示HA可通过降脂和抗炎双重作用防治AS。本项目以上述通路为靶点，研究沙生蜡菊花降脂部位的化学成分，考察降脂、抗AS部位及单体化合物对该通路的调节作用，进而阐明沙生蜡菊花降脂和抗炎活性的物质基础和作用机制。此研究可增进人们对上述通路与AS形成之间关系的认识，为防治AS药物的研发提供新思路

中文关键词： 沙生蜡菊花；动脉粥样硬化；化学成分；降脂；抗炎

英文摘要： Atherosclerosis (AS) serious harm to human health. At present, the main treatment of AS is mainly Western medicine which have serious great side effects and can not cure the diease. Furthermore, these medicine may bring great damage on the body when long-term used. The essence of AS is the inflammatory lesions which participated by lipid composition. Therefore, the prevention and treatment of AS would be more effective if the medicine both have the effective of lipid-lowering and anti-inflammatory. Chinese medicine have the advantages of weak side effects and wide filter range. So far, there have no single herbs which both have the lipid-lowering and anti-inflammatory efficacy could be used for the prevention and treatment of AS. C-reactive protein (CRP) is the most strongest inflammatory markers in the inflammation process of AS. The pathway of CRP/CD32-NF-κB(p65)-VCAM-1 involved in the development of inflammation, and promote the formation of AS. We have found the lipid-lowering fraction of Flos Helichrysum arenarium. with anti-AS activity (HA) could reduce the NF-κB levels which induced by CRP for the first time, and this result suggesting that the HA may prevent AS by the dual role of lipid-lowering and anti-inflammatory. This project intends to take the CRP/CD32-NF-κB (p65)-VCAM-1 pathway as a target, and s

英文关键词： Helichrysum arenarium (L.) MOENCH；artherosclerosis；chemical constituents；lipid-decreasing；anti-inflammatory